Nuedexta is a drug that is effectively used to treat pseudobulbar affect which is a disorder that occurs in patients who have suffered a stroke, multiple sclerosis, or ALS. The condition causes the sufferer to laugh and cry inappropriately and involuntarily. The drug acts on the brain of such patients to prevent these outbursts. Nuedexta contains a combination of quinidine and dextromethorphan. Dextromethorphan would affect the signals in the brain that trigger cough reflex. Hence, it is mostly used as a cough suppressant. On the other hand, Quinidine affects the way how the heart beats. Hence, it is primarily used to treat patients with certain heart rhythm disorders. This article provides information on what is Nuedexta savings card.
Nuedexta is not recommended for patients who have heart disorders. Also, you should not use the drug if you have used a MAO inhibitor within the past 15 days. A dangerous drug interaction could occur under such circumstances. Nuedexta is not recommended for patients who have had serious allergic issues in the past. If you are taking quinine, quinidine, or mefloquine, you need to avoid this drug. You should tell your doctor if you are taking any other medications at the time of being prescribed this medication. The reason for talking to your physician is because some medicines can interact with Nuedexta.
The drug should be taken exactly as prescribed by your health care provider for the drug to work effectively. Don’t neglect the directions on your prescription label. Don’t take the medicine in larger or smaller amounts and for longer than the prescribed period. The drug is usually prescribed as one capsule per day for the first seven days and one capsule every 12 hours after that. You should not take more than two pills within 24 hours. You can take the capsules with or without food. Your doctor will check your progress on a regular basis and alter the dosage accordingly.
Ask your doctor before using a cough or cold medication while you are taking Nuedexta. Grapefruit or grapefruit juice can interact with the medicine and cause unwanted side effects. Hence, you should avoid these things when taking the medication. These are important things to consider when taking Nuedexta.
Saving Money with the Nuedexta Savings Card
Unfortunately, the cost of Nuedexta is quite high, especially if your health insurance does not cover your medication. It costs around $850 for 60 capsules. But there is a way to reduce the price of this drug by at least 60-75%. That is by using a Nuedexta savings card. Many websites offer Nuedexta savings cards to patients. But you need to choose a reliable website to get your discount card. That may not be an easy task with a host of Nuedexta discount sites functioning out there.
Discount programs for drugs work similar to how you get discounts on motel rooms by using the AAA card. The savings card for Nuedexta is ideal for people who don’t have health insurance, self-employed individuals, and seniors. All big pharmacies and drug stores such as Rite Aid, CVS, and Walgreens accept the card. In fact, most of the independent pharmacies also accept the card. This card shouldn’t be confused with health insurance since the card is ideal for drugs that are not covered by your plan.
Nuedexta is a drug that is used to help people to manage emotional outbursts. It is often used to manage uncontrollable crying. Some individuals who suffer from MS benefit from taking Nuedexta, and the drug has been approved for use in the United States since 2010 but has taken longer to be approved in other parts of the world.
In the United Kingdom, Nuedexta was approved for use to treat certain MS symptoms in 2013, but it is a prescription only drug, and its use is limited to the treating of things like uncontrollable emotional outbursts in MS sufferers. Around ten percent of people who live with MS suffer from uncontrollable bouts of tears or laughter, which are disproportionate to the person’s real emotional state. The condition can be embarrassing, confusing and even distressing for both the sufferer and for the people who care for them or work with them.
The condition is known as Affective Release, and it is thought to be caused by the MS-related nerve damage that builds up over time. MS can damage the nerves in the brain that control both the way emotions form and the way they are regulated, which is what causes the disproportionate expression of emotion.
One difficulty surrounding Affective Release is that it makes it hard to tell when someone with MS is feeling troubled, and this means that real issues are not taken as seriously as they might be. Nuedexta helps to regulate the mood and the expression of emotion in people with MS, and this means that it is easier for those people to express difficulties and to get help when they need it.
Nuedexta can help individuals who have Affective Release, and the PseudoBulbar Affect because of other medical issues as well, but this is something where exploration is still occurring in the UK. In the United States, Nuedexta has been tested extensively, and it has been found that within one week of taking it, sufferers experience 44 percent fewer episodes of uncontrolled laughing or crying, and within 12 weeks, they experience 82 percent fewer episodes. Almost one-third of people who take the drug find that they completely stop experiencing events within the first two weeks of taking the drug.
Nuedexta is just one example of a new, life-changing drug that has come on the market in the last few years. Drugs like this need to be monitored carefully and extensively tested before they are released onto the market because there are so many risks associated with them. While Nuedexta is generally considered to be safe, the FDA and similar organisations in the UK, India, and Europe are concerned about making sure that drugs are as safe as possible. This safety measure means ensuring that they are not addictive and that they are not going to cause any lasting harm or interact with other medications. It takes many years to put a drug through that approval process.
PseudoBulbar Affect (PBA) affects approximately 2 million people within the United States and much more worldwide. It is a neurological condition and is often associated with different types of brain injuries, including those that occur with a stroke, multiple sclerosis, Parkinson’s disease and Alzheimer’s. The most common symptom of PBA is an uncontrolled and inappropriate laughing or crying. The only FDA approved treatment for the symptoms of PBA is Nuedexta.
Nuedexta contains two primary ingredients, dextromethorphan, and quinidine. These medications have been used separately for the treatment of other conditions, but when used together, they may be able to help reduce or eliminate the symptoms of PBA in some individuals. In clinical trials, it has been shown that it reduced the involuntary laughing and crying that is associated with the condition. In fact, in a 12-week study, patients experienced, on average, 82% fewer episodes of PBA. These results are promising, considering that a placebo only led to a 45% reduction. Over half of the patients had eliminated PBA episodes by the final two weeks of the study.
Avanir Pharmaceuticals is a biopharmaceutical company that is primarily focused on producing medicines that help individuals who have disorders of the central nervous system. One of those medications, available by prescription only, is Nuedexta. In October 2010, Avanir Pharmaceuticals obtained approval for Nuedexta from the US Food and Drug Administration (FDA). Since then, they had also received marketing authorization from the European Union in 2013. As of this date, it is approved for use in the United States, European Union, Norway, and Iceland.
The two different medications in Nuedexta work in conjunction with each other to reduce the symptoms of PBA. Dextromethorphan is commonly prescribed as a cough suppressant on its own. It affects the brain cycles that trigger the reflex of coughing. It is not effective at treating coughing associated with asthma, smoking or emphysema. Quinidine is commonly prescribed on its own as an antiarrhythmic medication to treat conditions such as atrial flutter and atrial fibrillation. It may also be used for the treatment of malaria.
It’s not entirely understood how the combination of medications works to reduce the symptoms of PBA. It is thought, however, that it regulates excitatory neurotransmissions with the Sigma-1 receptor antagonist activity. It may also have an effect on the NMDA receptor antagonist activity as well. This effect is thought to be due to the actions of Dextromethorphan, with Quinidine helping to reduce how quickly the Dextromethorphan breaks down in the brain.
Nuedexta was given FDA approval after a phase III clinical trial. This clinical trial enrolled patients who had multiple sclerosis or Lou Gehrig’s disease. Over the course of 12 weeks, they were either provided with Nuedexta or a placebo. The study was conducted to determine if the crying and laughing episodes could be reduced. The study concluded that those events were reduced significantly by the group that used Nuedexta in comparison to those that used the placebo. A similar study was performed for CHMP approval.
When the drug was first introduced in 2006, the FDA did not give its approval. They felt, at the time, that there were some issues associated with heart rhythm safety. The concern was primarily over quinidine and the possibility that it led to QT prolongation, which could be linked to an increased risk of heart attack. Nuedexta was then reformulated so that a lower dose of quinidine was included. New studies were conducted so that approval could be received.
Although Nuedexta has been prescribed for use in those with PBA, it may also be prescribed for other conditions as well. Some physicians are giving the prescription for agitation associated with Alzheimer’s disease, and it may also be prescribed for severe depression as well. The doctor can make the determination why this medication should be prescribed.
Nuedexta has shown real promise in helping individuals with a critical condition to lead a life that is free of the symptoms. It may also be beneficial for other conditions as well. Talk to your doctor about the possibility of using this medication and discuss your current medication usage and medical history. You may just find that it is the best option for you.
Nuedexta also known as Dextromethorphan or quinidine is the prescription medication used for treating pseudobulbar affect which is a type of mental disorder which is characterized with an uncontrollable outburst of crying or laughing. The drug is typically prescribed at the lower dosages of a single capsule daily, to begin with. But, your physician may decide to increase this dosage when necessary.
The costs related to Nuedexta are significantly high, particularly when your medication has not been covered by an insurance plan. Without any types of patient assistance, this drug typically retails for about $850 for a bottle of 60 capsules. Fortunately, there is a way to lower the costs of Nuedexta significantly by as much as 75% when using a Nuedexta coupon or a Nuedexta discount from a website such as Internet Drug Coupons.com.
These websites also offer what is known as a Nuedexta manufacturer coupon that can contribute to additional savings. Below you can compare the discounts on offer and decide on which one will work best for you.
The Nuedexta Manufacturer Coupon
Various pharmaceutical manufacturers often offer discounts and coupons to ensure their medications are more affordable because the costs involved in the prescription drug are typically high. The manufacturer for Nuedexta provides what is known as the co-pay card which assists individuals who are on private insurance a way to decrease their payments made out-of-pocket to around $30 for a fill.
(<==Click on the image to the right for discounts on Nuedexta when using at participating pharmacies.)
The Nuedexta Internet Drug Coupon
This Nuedexta discount offers you a way to save up to 75% on the retail price. You can choose to print the coupon out directly from the Internet Drug Coupons.com site, have the coupon emailed to you, SMS coupon or request to receive your card through the mail. Some of the benefits of the Nuedexta Internet Drug coupon include some of the following:
•This is a discount program, dedicated for prescription medications, which is very similar to how an AAA card can obtain discounts when booking a motel room.
•This discount is a great option for individuals who have no drug coverage, donut-hole seniors and the self-employed.
•This Nuedexta Coupon is accepted at the big chains such as Rite Aid, CVS, Walgreens, Etc and many of the independent pharmacies. This coupon cannot be used with insurance but is an excellent choice for the medications that have not been covered by your insurance plan.
If you find out that you do not qualify for the Nuedexta manufacturer offer, you are still able to obtain a “reusable discount coupon” from the Internet Drug Coupons.com site. These Nuedexta coupons offer discounts from between 20 and 75% for every prescription fill which is accepted at just about all the pharmacies across the country. To receive a coupon that is the more convenient for you, just click on one of the options: SMS (Text), Email or Print button featured under the coupon images. All that is needed is to present the digital or paper voucher to a pharmacist when you collect your prescription to obtain a discount.
The Nuedexta Discount Card
(Save from up to 85% on your Nuedexta prescription with this discount saving card. Click the image just below.)
Because you can reuse many of the coupons, you may want to take advantage of your Nuedexta coupons in a wallet-sized and durable savings card. This Rx Savings Card can be used for Nuedexta along with thousands of various other prescription drugs and offers the same discount of 20 to 75% discount like the regular coupons do. To apply for your card just click on the link “Free Rx Card” and “Get Card in Mail.” You can expect the card to arrive in 2 weeks which you can use immediately.
PseudoBulbar, more commonly referred to as PBA, can cause untold heartache, embarrassment, and frustration for people who suffer from the condition. That is why finding a treatment that works is certainly a worthwhile pursuit. If y ou, or someone you know, suffers from PBA, you may have heard that Neudexta can be used to treat the condition. Is this a viable option? Let’s take a look at a few of the details involved.
What Is PBA?
To understand whether a particular treatment has the potential to make a difference in the life of the patient; it is important to understand the nature of the condition.
PBA is seen in people with certain neurological conditions or brain injuries. The condition or injury causes damage to the brain area responsible for controlling how emotions are expressed. In effect, the brain signals can become disrupted; this disruption shows itself in the form of episodes of laughing or crying. These episodes are involuntary and spontaneous.
In general, the outburst of emotion can be described in one of the following main ways:
In the case of inappropriate outbursts, the person may suddenly begin to cry or laugh, even though the way they feel does not match their outward outburst.
Exaggerated outbursts may have an emotion that matches the situation. However, the sentiment is expressed much more intensely or for a longer period than would be viewed as normal.
Interestingly, the name of this condition very well describes the effect it has on a person’s life. ‘Pseudo’ means false and ‘bulbar’ means brainstem, indeed an appropriate term to describe such involuntary outbursts which do not reflect how the person actually feels.
What Are The Main Symptoms Of PBA?
The typical symptoms that a person suffering from PBA will display are outlined below:
– A neurological disease or brain injury
– Outbursts of crying or laughing
– Outbursts which are uncontrollable
– Outbursts which are brief
– Outbursts which are exaggerated
– A lack of connection between outbursts and underlying feeling.
A Look At How Nuedexta Can Treat PBA
Now that we have a clear understanding of PBA, including the typical symptoms and why the condition exists, it will be easier for us to understand how a particular treatment can make a difference. Indeed it is already clear that PBA is a condition which can cause considerable upset and embarrassment, hence finding an appropriate treatment could make a significant difference for good.
Neudexta has been approved by the U.S. Food and Drug Administration for the treatment of PBA. A study known as the PRISM II Study showed considerable improvement of PBA in patients who have Alzheimer’s, traumatic brain injury, stroke, as well as other forms of dementia. The study saw a noted improvement in the number of uncontrollable episodes from which each patient suffered. In fact, the baseline was around 12 outbursts per week, however after 90 days using this treatment they had decreased to an average of two per week, a very noteworthy finding.
A closer look at a few more details of the study gives further evidence as to how effective Neudexta can be in easing the embarrassment and frustration experienced by people who suffer from PBA. The study included 367 participants over the course of 90 days. At the end of the study clinicians said that in 77% of the participants the PBA symptoms were either ‘much improved’ or ‘very much improved.’
So What Is Nuedexta?
Since it seems clear from the PRISM II study that a significant body of evidence exists in support of the use of Nuedexta to treat PBA, it would be interesting to understand what makes up the drug. Details of the two principal components are outlined below:
This element is active in the central nervous system.
This component combines well with the dextromethorphan as mentioned above. Being a metabolic inhibitor, it allows for appropriate concentrations of dextromethorphan
It is also vital to understand that Nuedexta can interact with other medications which are currently being taken by the patient. The doctor will either make an adjustment to the dose of the current medication or use a different treatment if this seems to be the best option.
How Is Nuedexa Administered To Treat PBA?
Nuedexta is an oral drug and is administered in capsule form. A patient will start by taking one capsule each day for a full week. At the commencement of the second week, the dosage will increase to two capsules daily. The pills are given separately, with one being given every 12 hours. Two capsules are the maximum dose, and patients should never take more than this within a 24 hour period. If a patient misses a dose, they should simply skip it and wait until the next scheduled dose.
Do Any Self Assessment Tools Exist For People Who Think They May Be Suffering From PBA?
There are five key elements that people can think about when considering whether PBA may be a problem for them or for someone they know. These five elements are outlined below:
– Does the person have a neurological condition? (This may be multiple sclerosis, stroke, traumatic brain injury and such like)
– Does the person have involuntary outbursts of laughter or crying?
– Does the person burst out laughing or crying in situations which are not appropriate?
– Does the person have emotional outbursts which seem exaggerated concerning the situation?
– Does the person find it impossible to control their outbursts, even when they try to?
Analyzing the answers to the above five questions should put you in a good position to decide whether you or someone you know, may potentially be suffering from PBA. In fact, even if you do not answer yes to all of the above questions, PBA may still be an issue. In general, if your reply to the first question, as well as at least one of the other problems, is yes, you should raise PBA as a potential problem.
Family members, as well as friends, of a person suffering from PBA, will likely recognize that such outbursts are not usual, with the matter becoming a cause for concern. It is important to remember that a person who is suffering from PBA is undergoing a stressful condition. The outbursts can cause embarrassment and frustration for the sufferer, even having a significant impact on their relationships and their desire to engage in social activities. It stands to reason that finding a treatment which can reduce both the frequency and the severity of such outbursts could certainly contribute to an improved outlook and enhanced social opportunities for the person with PBA.
How Quickly Can Nuedexta Make A Positive Impact On Someone who Is Suffering From PBA?
The positive response to Nuedexta can be seen within a short period, in fact in as little as one week, symptoms of PBA can be significantly reduced.
Indeed the road to having Nuedexta approved and its start to make a positive impact on the lives of people suffering from PBA has been a long one. It has taken ten years of research and development for Neudexta to be approved. For patients who respond to Neudexta, the change to their quality of life can be very significant. The treatment can give people the opportunity to get more enjoyment from life, something which PBA can certainly hinder.
Nuedexta is the brand name of the drug dextromethorphan hydrobromide/quinidine sulfate manufactured by Avanir Pharmaceuticals for the treatment of neurological disorders. It is the first prescription medication, and the only FDA-approved the drug for the treatment of PBA or PseudoBulbarAffect. Neudexta consists of a combination of dextromethorphan and quinidine, two medicines used separately in the treatment of other conditions. It is taken orally in capsules of 20mg and 10mg strengths.
Generic Version Of Neudexta
Currently, there is no approved version in the United States that is therapeutically equivalent to Neudexta. Any attempt by fraudulent online providers to sell a Neudexta generic version is illegal and counterfeit and may be potentially harmful. Anyone who purchases medications online must ensure that they are dealing with legitimate and valid online pharmacies. It is best to consult your health care provider if there is any doubt about the legitimacy of a pharmacy before purchasing medication online.
How Does Neudexta Work?
Neudexta is a combination of dextromethorphan (generally found in cough syrup to suppress a cough) and quinidine (used in the treatment of certain neurological disorders).
Dextromethorphan acts on the signals from the brain that trigger the cough reflex to suppress a cough. Quinidine has an effect on the heartbeat and is used to treat certain disorders in heart rhythms.
Neudexta is the combination of these two medications and is utilized in the treatment of certain neurological disorders to treat people who suffer from the involuntary outburst of laughing and crying, as well as ALS (amyotrophic lateral sclerosis) also known as Lou Gehrig’s Disease. It is also the only medication prescribed and approved for the treatment of PsedoBulBarAffect (PBA). The drug belongs to the drug class: “miscellaneous central nervous agents” and contains 20mg of dextromethorphan and 20mg quinidine. It is currently not classified as a controlled substance under the CSA (Controlled Substance Act).
The Benefits Of Neudexta
Avanir Pharmaceuticals said in a news release that the combination of dextromethorphan and quinidine is thought to have an effect on the neurotransmitter “glutamate.” They presented a drug study at the annual American Academy of Neurology meeting in Toronto that showed that patients reported a decrease in episodes of involuntary laughing and crying while on the drug. The FDA initially withheld approval of Neudexta in 2006 due to safety concerns that quinidine could cause an abnormal increase in heart rhythms. Avanir Pharmaceuticals reformulated the formula to contain a safer level of quinidine.
PseudoBulbar Affect is a secondary effect of a range of neurological conditions and is characterized by sudden, involuntary and frequent episodes of crying or laughing. The approval by the FDA of using Neudexta to treat Pseudobulbar Affect represents a positive step forward for patients suffering from the debilitating effects of PBA according to the vice president of the Healthcare Delivery & Policy Research at the National MS Society.
Neudexta is not to be taken by anyone allergic to the ingredients quinidine or dextromethorphan or by those suffering from heart disease, a history of heart rhythm disorder, a history of Long QT syndrome or current use of mefloquine, quinidine or quinine. Do not take Neudexta if you have used a MAO inhibitor within the past 14 days as it may cause a dangerous drug interaction. Neudexta should not be taken without the supervision of your doctor as there is an extensive list of medications that may cause unwanted or hazardous side effects when taken with Neudexta and your drug protocol may have to be adjusted.
If you or a loved one is suffering from ALS, you are probably looking for medications that will help you to manage your symptoms. You may want to talk to your doctor about Nuedexta. While this medication has traditionally been used to help people with bouts of uncontrollable laughter, it has proven effective for treated some symptoms.
Should you use this medication? Here are a few of the benefits that it offers.
It’s The Only Medication That Is FDA Approved To Treat PBA
If you have issues with PBA, and you are looking for treatment, this is the medication that you are going to want to look at. At the time of writing, it is the only drug that has been approved by the FDA for this use.
While PBA symptoms can be very similar to depression symptoms, the two have very different causes. You can’t treat PBA like you would treat depression. You need to use a drug that will be a better fit for your specific issues.
It Was Developed By A Neurologist
A lot of medications were created by someone that has a limited understanding of neurology. However, that isn’t true of Nuedexta. This particular drug was designed by a neurologist. This is why it can do things that a lot of other medications can’t.
The drug was created by Dr. Richard A. Smith, who has worked with the Center for Neurologic Study for quite some time. He has a lot of experience with ALS patients, and he has a better understanding of their needs then many of the people developing pharmaceuticals do.
We Have A Lot Of Information About How It Works
There are some drugs on the market that are still very experimental. We only have a limited amount of information about how they work. Luckily, this isn’t true when it comes to Nuedexta. A number of studies have been conducted, and we know exactly how it impacts the brain.
This drug impacts sigma-1 and NMDA receptors in the brain. It has had a positive effect for a lot of people, and it works very quickly.
It Is Supported By Organizations And Doctors Alike
A number of respected doctors have spoken out in favor of this wonderful medication. ALS Worldwide has also sung the praises of this medicine. It’s done a lot of good, and that means that it has received a ton of support.
People aren’t usually willing to get behind medications like this unless the medications have delivered results. This medication has helped many, many patients, and it will help even more patients in the future.
It Has Minimal Side Effects
Obviously, side effects are always going to be a concern with medication. This is particularly true for people with serious conditions like ALS. Side effects can be devastating when you are already trying to cope with a serious condition. This drug isn’t completely free of side effects; some patients have encountered minor side effects. With that said, the effects aren’t particularly severe.
You should speak to your doctor about the side effects. You may be pleasantly surprised when you realize how few side effects this medication has. A large number of people have been able to take it without a problem.
Ultimately, you and your doctor are going to have to decide whether or not you should use Nuedexta to treat ALS. With that said, you should definitely bring this medication up at your next doctor’s visit. Talk about the benefits of this medication and see what your doctor thinks about it. They may wind up writing you a prescription.
You may recall the Neudexta facts commercial from a few years back that in which the famous actor Danny Glover starred. Many people watched that TV commercial not knowing what it was about. Those who have Pseudobulbar affect (PBA), have a better understanding the condition and appreciate the efforts of the advertisements to provide more insight into the issue and facts about Nuedexta as a treatment for the problem.
A few more commercials about PBA and the Nuedexta drug for treatment are provided below. These Nuedexta ads are quite telling and connect with people who are subject to PBA condition. Watch the PBA Commercials provided below to understand the Pseudobulbar affliction.