Nuedexta Generic Version

Generic Nuedexta

Nuedexta is the brand name of the drug dextromethorphan hydrobromide/quinidine sulfate manufactured by Avanir Pharmaceuticals for the treatment of neurological disorders. It is the first pGeneric form of Nuedextarescription medication, and the only FDA-approved the drug for the treatment of PBA or PseudoBulbarAffect. Neudexta consists of a combination of dextromethorphan and quinidine, two medicines used separately in the treatment of other conditions. It is taken orally in capsules of 20mg and 10mg strengths.

Generic Version Of Neudexta

Currently, there is no approved version in the United States that is therapeutically equivalent to Neudexta. Any attempt by fraudulent online providers to sell a Neudexta generic version is illegal and counterfeit and may be potentially harmful. Anyone who purchases medications online must ensure that they are dealing with legitimate and valid online pharmacies. It is best to consult your health care provider if there is any doubt about the legitimacy of a pharmacy before purchasing medication online.




How Does Neudexta Work?

Neudexta is a combination of dextromethorphan (generally found in cough syrup to suppress a cough) and quinidine (used in the treatment of certain neurological disorders).

Dextromethorphan acts on the signals from the brain that trigger the cough reflex to suppress a cough. Quinidine has an effect on the heartbeat and is used to treat certain disorders in heart rhythms.

Neudexta is the combination of these two medications and is utilized in the treatment of certain neurological disorders to treat people who suffer from the involuntary outburst of laughing and crying, as well as ALS (amyotrophic lateral sclerosis) also known as Lou Gehrig’s Disease. It is also the only medication prescribed and approved for the treatment of PsedoBulBarAffect (PBA). The drug belongs to the drug class: “miscellaneous central nervous agents” and contains 20mg of dextromethorphan and 20mg quinidine. It is currently not classified as a controlled substance under the CSA (Controlled Substance Act).

The Benefits Of Neudexta

Avanir Pharmaceuticals said in a news release that the combination of dextromethorphan and quinidine is thought to have an effect on the neurotransmitter “glutamate.” They presented a drug study at the annual American Academy of Neurology meeting in Toronto that showed that patients reported a decrease in episodes of involuntary laughing and crying while on the drug. The FDA initially withheld approval of Neudexta in 2006 due to safety concerns that quinidine could cause an abnormal increase in heart rhythms. Avanir Pharmaceuticals reformulated the formula to contain a safer level of quinidine.




PseudoBulbar Affect is a secondary effect of a range of neurological conditions and is characterized by sudden, involuntary and frequent episodes of crying or laughing. The approval by the FDA of using Neudexta to treat Pseudobulbar Affect represents a positive step forward for patients suffering from the debilitating effects of PBA according to the vice president of the Healthcare Delivery & Policy Research at the National MS Society.

Precautions

Neudexta is not to be taken by anyone allergic to the ingredients quinidine or dextromethorphan or by those suffering from heart disease, a history of heart rhythm disorder, a history of Long QT syndrome or current use of mefloquine, quinidine or quinine. Do not take Neudexta if you have used a MAO inhibitor within the past 14 days as it may cause a dangerous drug interaction. Neudexta should not be taken without the supervision of your doctor as there is an extensive list of medications that may cause unwanted or hazardous side effects when taken with Neudexta and your drug protocol may have to be adjusted.

Using Nuedexta for the Treatment of Dementia

Dementia Treatment using Nuedexta

Like many medications, Nuedexta may be used for a variety of purposes. Primarily, it is prescribed for a specific mental or mood disorder that is known as the pseudobulbar affect. This particular disorder is associated with a number of brain conditions, including ALS, stroke and multiple sclerosis. There is also some research to show that it may be beneficial for use in individuals who are suffering from dementia.

There are 2 different active ingredients in Nuedexta that work together to help control the symptoms of pseudobulbar affect. One of those medications is dextromethorphan, which is typically prescribed as a cough suppressant. It works in the brain by affecting the signals that may cause the cough reflex to trigger. It is not prescribed for coughing that is associated with asthma, emphysema or other similar lung conditions. This may help with the outbursts of inappropriate and uncontrollable laughing or crying associated with that condition. The other drug, quinidine, increases how dextromethorphan works in the brain.




Interestingly, there have been some recent studies showing that the combination of drugs in this medication may not only help individuals with pseudobulbar affect, it may also help individuals with Alzheimer’s

Senile elderly man taking daily medicine at the nursing home.

 

disease who are experiencing dementia. The study involves some 220 patients suffering from Alzheimer’s and the drug was shown to have a positive effect on their agitation over the course of the 10 week trial.

Alzheimer’s is the leading cause of dementia, although it is not the only type. Dementia may also be caused by additional issues, such as Parkinson’s disease, vascular dementia and dementia with Lewy bodies. It all has the same general effect, however, and that is causing an individual to lose cognitive abilities to the point where it interferes with their daily life.

It has not been shown if Nuedexta is effective in treating other types of dementia other than Alzheimer’s dementia. Further studies may be necessary in order to test that possibility.

son of dad with AlzheimersOne of the positive aspects of the test dealing with Alzheimer’s patients is the fact that it eased the symptoms of agitation but did not worsen the symptoms of dementia, including thinking, memory and judgment. Aggression is a common sign of dementia as it continues to progress. It may start out with some restlessness but eventually, could lead to aggressive behavior such as fighting, yelling or destroying things.

Physicians feel that it is always best to manage problems associated with dementia without medication if at all possible. There are going to be times, however, when individuals need medication to control those symptoms. Some of the antipsychotic drugs developed for bipolar disorder or schizophrenia, for example, are often used for individuals with dementia. Those medications can have some severe side effects, however, and may even promote an accelerated mental decline along with heart complications.



Nuedexta may provide a solution to help ease the problem with aggression in dementia patients without having to use those other, more dangerous drugs. There are some potential side effects associated with Nuedexta but they tend to be less difficult to manage as those associated with antipsychotic drugs. Some of those potential side effects can include dizziness, digestive upset, weakness, swelling in the extremities and drowsiness. As with taking any medication, it would be necessary to monitor the possibility for side effects and report anything to the physician.

The decision as to whether to prescribe Nuedexta for the treatment of dementia is one that is up to the doctor. Additional test will continue to be run to see if it is a viable solution for the treatment of aggression in Alzheimer’s dementia patients. The tests that were done so far, however, appeared to be positive in the fact that it did treat the aggression but did not hasten the mental decline that may be seen with the use of other drugs.

It is interesting to note, however, that physicians do have the ability to prescribe medications for uses other than the primary use if they feel it is appropriate to do so. It may be worth speaking to your doctor if you have a loved one with dementia and would like to see if the medication could control the aggression that they are experiencing.

Should You Use Nuedexta To Treat ALS

If you or a loved one is suffering from ALS, you are probably looking for medications that will help you to manage your symptoms. You may want to talk to your doctor about Nuedexta. While this medication has traditionally been used to help people with bouts of uncontrollable laughter, it has proven effective for treated some symptoms.

Should you use this medication? Here are a few of the benefits that it offers.

It’s The Only Medication That Is FDA Approved To Treat PBA

If you have issues with PBA, and you are looking for treatment, this is the medication that you are going to want to look at. At the time of writing, it is the only drug that has been approved by the FDA for this use.

While PBA symptoms can be very similar to depression symptoms, the two have very different causes. You can’t treat PBA like you would treat depression. You need to use a drug that will be a better fit for your specific issues.




It Was Developed By A Neurologist

A lot of medications were created by someone that has a limited understanding of neurology. However, that isn’t true of Nuedexta. This particular drug was designed by a neurologist. This is why it can do things that a lot of other medications can’t.

The drug was created by Dr. Richard A. Smith, who has worked with the Center for Neurologic Study for quite some time. He has a lot of experience with ALS patients, and he has a better understanding of their needs then many of the people developing pharmaceuticals do.

We Have A Lot Of Information About How It Works

There are some drugs on the market that are still very experimental. We only have a limited amount of information about how they work. Luckily, this isn’t true when it comes to Nuedexta. A number of studies have been conducted, and we know exactly how it impacts the brain.

This drug impacts sigma-1 and NMDA receptors in the brain. It has had a positive effect for a lot of people, and it works very quickly.

It Is Supported By Organizations And Doctors Alike

A number of respected doctors have spoken out in favor of this wonderful medication. ALS Worldwide has also sung the praises of this medicine. It’s done a lot of good, and that means that it has received a ton of support.

People aren’t usually willing to get behind medications like this unless the medications have delivered results. This medication has helped many, many patients, and it will help even more patients in the future.

It Has Minimal Side Effects

Obviously, side effects are always going to be a concern with medication. This is particularly true for people with serious conditions like ALS. Side effects can be devastating when you are already trying to cope with a serious condition. This drug isn’t completely free of side effects; some patients have encountered minor side effects. With that said, the effects aren’t particularly severe.




You should speak to your doctor about the side effects. You may be pleasantly surprised when you realize how few side effects this medication has. A large number of people have been able to take it without a problem.

Ultimately, you and your doctor are going to have to decide whether or not you should use Nuedexta to treat ALS. With that said, you should definitely bring this medication up at your next doctor’s visit. Talk about the benefits of this medication and see what your doctor thinks about it. They may wind up writing you a prescription.

What are some of the Drug Nuedexta Uses

Uses of Nuedexta and Considerations

What is Nuedexta?
Nuedexta is a prescription medication manufactured by Avanir Pharmaceuticals, Inc. as a treatment for pseudobulbar affect. This drug features a precise combination of dextromethorphan and quinidine which affect reaction in the brain and heart.

Dextromethorphan is a morphine class drug used to interrupt signals from the brain and is most often used as a cough suppressant. As a matter of fact, Dextromethorphan is the active ingredient found in “Robitussin” the popular cough syrup.

Quinidine affects the heartbeat and is often the prescription for people who suffer from arrhythmia or an irregular heartbeat disorder.

The combination of the two in Nuedexta is designed to treat the condition of pseudobulbar affect, which is associated with involuntary bouts of laughing of crying for no apparent reason. This condition is often found in people with neurological disorders, including ALS (Lou Gehrig’s disease or amyotrophic lateral sclerosis) or multiple sclerosis.

The primary indication of a PBA condition includes these uncontrollable bursts of laughter or tears with no prior warning. There is also no reason for the greatly exaggerated reaction and are often not connected to the emotional state of the individual. Tears can quickly change to laughter, and the reverse is also true. Furthermore, these extreme mood swings can occur at any time and despite periods of normal temperament.

One of the most striking characteristics of the condition is the intensity of the emotional response, which means laughter and tears can last for long periods of up to several minutes in response to a vaguely funny or somber remark. The important thing to note is the high contrast in the reactions the individual would have provided before the condition.




Often people who suffer from the disease experience both symptoms simultaneously. However, crying is often the more common symptom of the condition. For this reason, the condition is often confused with a state of manic and uncontrollable depression. The difference between the two is that depression is a constant state, whereas PBA comes and goes in dynamic episodes. Furthermore, those with PBA don’t exhibit the same symptoms of sleeplessness, lethargy, and loss of appetite that those with depression experience.  Nevertheless, depression is quite commonly a result of a PBA condition as it begins to interfere with everyday living.

The most common causes of PBA involve neurological damage caused by injury or disease. These complications can directly affect the emotional response center of the brain and cause this confused response. Following are some of the most common causes for PBA and the need for the use of

Drug Uses Nuedexta:

–Multiple Sclerosis
-Parkinson’s Disease
-Alzheimer’s Disease
-ALS (amyotrophic lateral sclerosis)
-Traumatic brain injuries
-Stroke

Complications Associated with PBA and Treatment with Nuedexta

There are moderately severe symptoms associated with PBA that can be cause for anxiety, depression, social isolation as well as the embarrassment in social situations. As it often accompanies a neurological condition, this can affect your capacity to cope with routine tasks and lead an ordinary life. Helping lead to a normal life is where Nuedexta is most often prescribed to interrupt these emotional responses and add a measure of control over one’s life. Nevertheless, there is some important consideration for taking this innovative medication.

Considerations for Using Nuedexta Medication

Those with a history of heart failure should consider taking Nuedexta a significant risk due to its heart affecting properties. One condition, in particular, is called “AV Block” and Long CT syndromes are especially critical and Nuedexta should not be used if these are a current concern.

Furthermore, you don’t want to use Nuedexta if you have your MAO inhibitor within the last two weeks. MAO inhibitors contain a volatile assortment of medication including linezolid, isocarboxazid, and methylene blue injection. This combination could produce a dangerous drug interaction with severe consequences.

If you are currently taking quinine, quinidine or mefloquine, you are also not a likely candidate for Nuedexta treatment. The same holds true if you have ever presented any allergic reactions to these medications.
Many other medicines have the capacity to react with Nuedexta or at the very least adversely affect the efficacy of the drug. It is essential that you counsel with your medical provider and informs them of all current medications before receiving your Nuedexta treatment.




Final Notes: the use of Nuedexta can only be efficient if properly assimilated by the body. CYP2D6 is a protein that affects how quickly the drug is eliminated from the bloodstream and body. People with high amounts of this protein, will not fully absorb the medication and the effects will be severely impaired. Furthermore, these “poor metabolizers” can present a greater chance of reacting poorly to the quinidine content. Testing can be done for levels of CYP2D6 to determine personal tolerance for the drug.

If you are considering Nuedexta for the treatment of PBA or any other condition, it is essential that you visit a qualified medical practitioner to ensure the best possible outcome for your medication.

Danny Glover Nuedexta Commercial for Pseudobulbar affect (PBA)

Commercial for Nuedexta


You may recall the Neudexta facts commercial from a few years back that in which the famous actor Danny Glover starred.  Many people watched that TV commercial not knowing what it was about.  Those who have Pseudobulbar affect (PBA), have a better understanding the condition and appreciate the efforts of the advertisements to provide more insight into the issue and facts about Nuedexta as a treatment for the problem.




A few more commercials about PBA and the Nuedexta drug for treatment are provided below. These Nuedexta ads are quite telling and connect with people who are subject to PBA condition. Watch the PBA Commercials provided below to understand the Pseudobulbar affliction.

Can Nuedexta to Be Used for Depression

In the United States, almost 15 million adults suffer from some major depressive disorder. These adults account for approximately 7% of the population. This type of a problem can occur at any age and is more likely to occur in women than men. There are treatments for those who are depressed, but is Nuedexta one that can help an individual dealing with clinical depression?

Nuedexta drug for depression
Depression related documents and drugs

Nuedexta is a medication that is typically prescribed for a disorder known as the pseudobulbar affect (PSA). It occurs for various reasons that are associated with the brain. For example, individuals who have multiple sclerosis, suffer from a stroke or ALS may also experience pseudobulbar affect. There have been some reported cases of Nuedexta being prescribed to treat depression as well.

Pseudobulbar Affect results in symptoms that include uncontrollable outbursts of laughing or crying when an individual suffers from a neurological condition or a brain injury. It is not a new condition, but it has been described in medical literature for more than 130 years. It is more commonly a problem when brain injuries or neurological diseases affect an area of the brain that controls emotion or expression. For reasons that are not understood, the condition could trigger those uncontrolled laughing or crying episodes.




PSA is sometimes mistaken for depression, although they are two separate issues. It is noteworthy, however, that many individuals have both PSA and depression. Depression is an ongoing problem that may last for months, but episodes of PSA are typically spontaneous and may not be associated with what an individual is feeling inside.

The two ingredients found in Nuedexta are dextromethorphan and quinidine. It is not clear how the combination of medications in Nuedexta work to treat this problem. It is known that Dextromethorphan operates in the brain and that Quinidine is used along with that drug to increase its effect.

When a doctor prescribes Nuedexta for PSA, it may be possible that the individual who is suffering from the condition is also suffering from depression as well. As a result, they may feel that the medication is being prescribed to treat their depression when in fact, it is being used to treat PSA. The doctor may not have addressed the issue of the depression to the extent where he has prescribed medication for it.

That being said, there are also some doctors who have reportedly prescribed Nuedexta for individuals who suffer from depression. The results of those who use the medication may vary, but there are some reports that it has worked well for some people who may have tried other depression medication, such as Cymbalta or Abilify unsuccessfully.

Regardless of whether your doctor is prescribing Nuedexta for the treatment of PBA or depression, it is important to discuss the use of the medication with your doctor in detail. The need for this discussion is especially true when describing your medical history or any other medications that you may currently be using. In that way, your physician may be able to rule out the possibility of interactions or other issues.




Side effects may also occur when you use Nuedexta, although they do not occur in all people who use it. Those side effects can include dizziness, diarrhea, vomiting, weakness, coughing, swelling of the extremities and drowsiness. Any persistent or severe side effects from any medication should be reported to your doctor immediately.

Depression is a treatable condition, and it is one that can be discussed with your physician to find a solution to the problem. Regardless of whether this drug is considered or another medication, your doctor may be able to help you to find one that works right for you.

What are the Side Effects of Nuedexta

Nuedexta Side Effects


Nuedexta is an FDA-approved medication for treating PseudoBulbar Affect. It is a medical condition that leads to frequent, sudden and involuntary episodes of laughing and crying in people with brain injury or certain neurologic conditions. These episodes usually don’t match the feelings of a person.

While this medicine has been found to be effective for treatment of this condition, it also has certain side effects. Also, this medication is available only via a prescription. Here is a list of some of the common after additional effects of this medicine.

Other Effects of the  Drug Nuedexta

Nuedexta side effects

First and foremost, it is important for you to know that this medication can interact with other medications and supplements, and interaction with other drugs or supplements can lead to some serious concerns. Therefore, it is important for you to tell your doctor about all the other supplements and medications you are currently taking before you start taking this particular drug. You shouldn’t start taking other medications when you are taking Nuedexta without first talking to your doctor as it may lead to serious issues.



Some of the less common impacts include joint pain, diarrhea, fever, chills, blood in urine, vomiting,  and loss of appetite.  Additional after affects include a runny nose, unusual weight gain or loss, trouble sleeping, sore throat, rapid weight gain, muscle pain, lower back or side pain, general feeling of illness, bloating or swelling of feet, lower legs, hands or arms among other things.

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If you experience excessive sweating, confusion, blurred vision, hallucinations, hearing loss, loss of consciousness, restlessness, seizures, uncontrolled eye movements, twitching, shaking, or shortness of breath, it may be a symptom of overdose.  Severe sleepiness, a sensation of spinning, excitement, double vision, depression, dizziness, decreased responsiveness or aggressive behavior, may also be overdose symptoms. In such a situation, it is important for you to give a call to your doctor immediately.

In most cases, these things go away after some time as the body gets used to the new medication. However, you should get in touch with your doctor if these things continue after the first few days.

Nuedexta drug side effects – what to do

You should give a call to your doctor right away in case you experience fever, lightheadedness or vomiting as these may be due to an allergic reaction to this medication. If there is unexplained bruising or bleeding after taking this medicine, you should immediately get in touch with your doctor as one of the ingredients in this medication may lead to the reduction in the number of platelets in the blood. It is important to get it checked as quickly as possible as it can be fatal if left untreated.

As far as the recommended dose of this medication is concerned, doctors usually recommend one capsule a day for the first seven days, and two capsules a day after the first week. Also, this medication may interact with grapefruit juice and grapefruit as well as allergy medications, ADHD medications, antifungals, antibiotics, blood pressure medications and antidepressants.

In rare cases, this drug may also lead to increase in serotonin in your body. The risk of an increase in serotonin goes up if you are also taking other drugs containing serotonin enhancing agents. Therefore, it is important for you to tell your doctor about all the products you are currently taking.



Keep in mind that this drug may cause some serious problems if you have a family history of heart rhythm problems or you have had heart disease. This medication may lead to changes in the heart rhythm, and it may not be the right drug for you in case you have some heart problems. Another important thing you need to keep in mind is that you cannot take more know mono-amine oxidase inhibitors 14 days before or after taking this medication as it can lead to some significant issues of concern.

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Overall, the most common issues of this drug include weakness, vomiting, cough, dizziness, swelling of feet and ankles, and diarrhea. These issues usually go away after some days, but you should immediately give a call to your doctor in case any these effects do not go away after a few days. Also, you should immediately call your doctor if you experience restlessness, shivering, high blood pressure, confusion or twitching after taking this medication.

Possible PBA Treatment Nuedexta Drug Interactions

As a patient starting a new medication, it is always important to be aware of possible interactions and effects that may occur. This awareness is of particular importance when dealing with any drugs that can affect your mental health. This reason is why talking to your doctor before you start any medication, even over the counter while taking medication for depression or neurological issues is critical. You should also be careful drinking alcohol and cautious of any changes to your routine.

For Nuedexta, there are a large number of possible interactions from the drug, and many of them may make the symptoms that you are trying to treat much worse over time. These interactions are why people often feel that this treatment isn’t working for them, or why they have related feelings of being tired, sluggish, emotionally worn out, or having symptoms that are over the top.

Regarding foods, people taking Nuedexta should avoid eating grapefruit or drinking the juice when they are on the medication. The juice of this fruit was found to make the drug take longer to work entirely. In some people it even made it less effective over time, causing them to suffer more. No other types of citrus or food interactions were observed.

Alcohol was also found to have an adverse effect on people taking this drug. Patients who drank while on Nuedexta medication found themselves uncontrollably sleepy were unable to concentrate even on basic things and had increased levels of dizziness including when sitting down. Other people concluded that they were unable to think clearly at all, making them disoriented and feeling lost. Many others experienced impaired judgment that was detrimental to them, their health, or to others around them.

There have also been reported interactions with different levels of over the counter vitamins and herbs that were not approved for use with the medication. These are too numerous to list, but the symptoms included everything from breaking out in hives to an increase in multiple sclerosis progression. Most of these interactions were solved by talking with a doctor and altering or stopping the supplemental medication that was being taken at that time.




Other people found that Nuedexta increased the amount of time that different drug stayed in their body, making it more or less effective. This increase meant that they needed to adjust the dosage that they were taking to ensure that they were not damaging their organs, prolonging their effects, or mixing medications that should be kept separate. This interaction was positive in a few cases where it allowed patients to take less medication for better results.

Still, other interactions include medications causing the usage of Neudexta to be less effective or to take longer to achieve the desired effect. These are similar to the grapefruit juice effect mentioned earlier, and avoidance should be the effort at all costs.

No matter what you are thinking of taking while on the Nuedexta drug, you will need to talk with your doctor to ensure safety and that it will not be detrimental to your health. Be sure to bring any over the counter medication with you to your appointment.

drug interactions of Nuedexta

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