Nuedexta Clinical Trials

The Clinical Trails of Nuedexta Medication

Nuedexta is a drug which is being used to treat people who are suffering from a condition known as Pseudobulbar affect. Nuedexta is still quite a young, and untested drug, and there are a series of clinical trials being performed at the moment to determine the effectiveness and safety of the drug.

The Nuedexta clinical trials have, so far, been quite positive and promising. It should not be long before the drug is prescribed commonly to treat people with PBA. There are always safety concerns with new medications, and the outcomes of the clinical trials so far are being watched quite closely.

Nuedexta Has Been Licensed for Marketing in Some Parts of the World

Neudexta was given a marketing license in 2013 by the EMA. The license was withdrawn for EU marketing in 2016 and did not get licensed at all for marketing in the UK. For it to be licensed, it will need far more testing than it has had so far. The drug is still available in the USA.

Effects of Nuedexta Studied in Clinical Trials

One of the most recent Nuedexta clinical trials focused on the effects of the drug on nursing home patients who suffered from PBA. The experiment spanned six months and looked at a total of 125 patients across several states. Unfortunately, evidence from this study was inconclusive because there was difficulty recruiting patients, so the study was terminated before the six month period was up.

Another study looked at the safety and tolerability of Nuedexta for managing PBR in people who had suffered from a range of conditions, including traumatic brain injury and dementia, as well as strokes. This study spanned 12 weeks and used a 20mg dose of Nuedexta. The study engaged 367 participants and showed promising results across several outcome measures relating to emotional episodes and other difficulties.

Nuedexta is Often Mis-Prescribed

red pills or capsules in blue background

Clinical trials have been promising when Nuedexta has been tested for PBA alone. However, there are some concerns about the safety of the drug and the way that it is prescribed. Recent research and studies into the prescription of the medication indicate that doctors often prescribe it to people who have dementia, Parkinson’s, or another underlying condition. This is concerning because the drug has not been tested for use in this way. It is uncertain whether there may be interactions between Nuedexta and other drugs, or whether it may have unexpected impacts on people who are suffering from other conditions. This is something that the medical community is calling for further research.

Technically, prescribing Neudexta for PBA that is associated with other underlying conditions is off-label. This is something that a lot of doctors and consultants overlook, but it should be a matter of significant concern given the potential for the drug to have unwanted side-effects.

Indeed, Medicare has asked that insurance companies monitor the prescription of Nuedexta. That’s because it is being marketed aggressively for dementia patients. Though, it has not been properly tested and trialed for that kind of use. It is also being marketed for Alzheimer’s. Other drugs are likely to be far better suited for managing the symptoms that people living with Alzheimer’s are experiencing. People who use Nuedexta for Alzheimer’s are more likely to experience falls, and other secondary issues, including UTIs, than those who are given more appropriate drugs.

One challenge that doctors face is that there are not many options for managing the behavioral issues associated with Alzheimer’s and dementia. It can be tempting to use something like Nuedexta, which may help with those issues in the short term. Unfortunately, Nuedexta is just a band-aid for such problems, and it is not going to manage the condition itself. In the vast majority of cases, it would be better for doctors to find ways to proactively slow the progress of Alzheimer’s or to find ways for the patient to cope with dementia without using an off-label drug that has not been tested for that kind of application. Doctors and nursing home workers are encouraged to avoid this kind of excessive over-prescription until more data is clarifying the safety of the drug.

What is the Nuedexta Savings Card

Learn More About The Savings Card for Nuedexta

Nuedexta Savings Card

Nuedexta is a drug that is effectively used to treat pseudobulbar affect which is a disorder that occurs in patients who have suffered a stroke, multiple sclerosis, or ALS. The condition causes the sufferer to laugh and cry inappropriately and involuntarily. The drug acts on the brain of such patients to prevent these outbursts. Nuedexta contains a combination of quinidine and dextromethorphan. Dextromethorphan would affect the signals in the brain that trigger cough reflex. Hence, it is mostly used as a cough suppressant. On the other hand, Quinidine affects the way how the heart beats. Hence, it is primarily used to treat patients with certain heart rhythm disorders. This article provides information on what is Nuedexta savings card.

Nuedexta is not recommended for patients who have heart disorders. Also, you should not use the drug if you have used a MAO inhibitor within the past 15 days. A dangerous drug interaction could occur under such circumstances. Nuedexta is not recommended for patients who have had serious allergic issues in the past. If you are taking quinine, quinidine, or mefloquine, you need to avoid this drug. You should tell your doctor if you are taking any other medications at the time of being prescribed this medication. The reason for talking to your physician is because some medicines can interact with Nuedexta.

The drug should be taken exactly as prescribed by your health care provider for the drug to work effectively. Don’t neglect the directions on your prescription label. Don’t take the medicine in larger or smaller amounts and for longer than the prescribed period. The drug is usually prescribed as one capsule per day for the first seven days and one capsule every 12 hours after that. You should not take more than two pills within 24 hours. You can take the capsules with or without food. Your doctor will check your progress on a regular basis and alter the dosage accordingly.

Ask your doctor before using a cough or cold medication while you are taking Nuedexta. Grapefruit or grapefruit juice can interact with the medicine and cause unwanted side effects. Hence, you should avoid these things when taking the medication. These are important things to consider when taking Nuedexta.

Saving Money with the Nuedexta Savings Card

Unfortunately, the cost of Nuedexta is quite high, especially if your health insurance does not cover your medication. It costs around $850 for 60 capsules. But there is a way to reduce the price of this drug by at least 60-75%. That is by using a Nuedexta savings card. Many websites offer Nuedexta savings cards to patients. But you need to choose a reliable website to get your discount card. That may not be an easy task with a host of Nuedexta discount sites functioning out there.

Discount programs for drugs work similar to how you get discounts on motel rooms by using the AAA card. The savings card for Nuedexta is ideal for people who don’t have health insurance, self-employed individuals, and seniors. All big pharmacies and drug stores such as Rite Aid, CVS, and Walgreens accept the card. In fact, most of the independent pharmacies also accept the card. This card shouldn’t be confused with health insurance since the card is ideal for drugs that are not covered by your plan.

(Get 10 to 85% of your prescription using the Nuedexta Prescription Discount Card by Clicking ==> Here)

Treating PBA With The Nuedexta Mechanism Of Action

Mechanism of Action – Nuedexta

PseudoBulbar Affect(PBA) is a highly unfortunate condition that is known for causing sudden bursts of laughter or crying in patients. These outbursts come on quickly and frequently occur throughout the day. In some cases, there may be slight sadness or amusement before an outburst, but most often the outbursts are completely unprovoked.

More than 2 million people in America have been diagnosed with PBA. Most of these patients have either suffered a brain injury or another serious neurological disorder. Also, there are another 7 million patients in the country with symptoms that suggest they may be affected by PseudoBulbar Affect. Nearly half of the people who suffer from a traumatic brain injury begin to display symptoms of PBA.

It should not be confused with a condition like depression, which may result in symptoms that seem similar at first. PBA causes extremely exaggerated emotional expressions. These expressions are rarely an indicator of how the patient actually feels. PBA is a neurological condition that stems from damage to the nervous system. Depression, on the other hand, is a psychological condition that stems from problems with the patient’s mental or emotional state.

Modern PBA Treatment.

Today, PBA is often treated with a drug called Nuedexta. This medication is a potent drug combination that was developed by Avanir Pharmaceuticals, who is also the manufacture the drug. They began producing the drug in 2013, and it has since grown to become an influential and popular source of treatment for this neurological condition.

Avanir has not released the exact mechanism of action for Nuedexta, but most professionals believe it works by regulating certain parts of the nervous system. More specifically, it controls neurotransmissions that use the sigma-1 receptor as well as the NMDA receptor. Meanwhile, it has also been shown to slow down the brains breakdown of dextromethorphan.

Each capsule contains a combination of two drugs. You will find them in either 20/10mg combinations or 30/10mg combinations. One drug is dextromethorphan hydrobromide and the second drug is quinidine sulfate.

Nuedexta was only approved by the FDA after extensive clinical trials. The most recent trial involved giving some patients Nuedexta and some patients placebo. The study was conducted for a total of 12 weeks, and professionals measured the frequency and length of episodes of crying or laughter.

The study yielded very positive results for Nuedexta. The patients that used the drug suffered from significantly fewer episodes of crying or laughter compared to the patients who were given the placebo.

Another study was conducted before receiving approval from the CHMP. This was a somewhat similar study that focused on judging the safety and effectiveness of the drug in a total of 325 patients. It lasted for a total of 12 weeks and had nearly the same results.

The Bottom Line

Nuedexta is still a relatively new drug for treating PBA. The exact mechanism of action isn’t entirely known either. Still, it is impossible to argue with such positive results. It seems to be a very reliable treatment for patients suffering from this unfortunate condition.

What We’ve Learned From Nuedexta Clinical Trials

Findings – Clinical Trials with Nuedexta

Nuedexta has been tested extensively, before and after its release. We’ve been able to glean a lot of information from these clinical trials. Today, we know far more about Nuedexta than we once did.
 
clinical research trial
 
What Kinds Of Results Have We Seen?
 
A lot of these trials have led to extremely positive results. Some of the most promising results involved using Nuedexta to treat people that have ALS. Studies have found that the drug can ease many ALS symptoms, including speech difficulties and issues with swallowing.
 
While a lot of these tests have been small in scale, the majority of the patients responded very positively to this drug. These studies have been extremely promising. New studies are being launched so that we can glean more information about the effectiveness of this medication.
 

The Goal Of These Studies

 
The primary goal of the research and studies involving Nuedexta is to find ways to treat ALS. Researchers are looking for ways to improve the quality of life for people with ALS. Medications like this are a big part of it.
 
Of course, not all of the clinical trials involving Nuedexta have been about ALS and ALS symptoms. There have also been studies that used Nuedexta to treat patients with Alzheimer’s Disease. People with Alzheimer’s often experience neurological problems. For example, people might have unexplained bouts of crying or laughter. Early research has shown that
Nuedexta can treat this effectively as well.
 
Nuedexta has even been tested on adults with autism. It seems clear that this medication can effectively treat all kinds of people with neurological disorders.
 
What’s Next?
What’s next for Nuedexta? While the medication has been approved by the FDA and is being prescribed now, experts still want to learn more about it. There will continue to be clinical trials involved Nuedexta in the future.
It is unlikely that this medication will be changed in any major way. However, it is possible that the drug will be prescribed to a larger number of people. Because trials have shown that it can treat a range of issues effectively, it seems likely that a growing number of doctors are going to be prescribing this drug to their patients.
 
At this current point in time, it seems unlikely that doctors will be prescribing Nuedexta to children. It is challenging to confirm that a medication like this is safe for children to take.
 
However, it is likely that this drug is going to be given to a growing number of people. As doctors learn more about this drug and what it is capable of, they will be far more likely to recommend it to their patients in the future.
 
Nuedexta clinical trials have provided us with a lot of valuable insight. Thanks to these tests, doctors will be able to prescribe Nuedexta to people that will benefit from it greatly. Hopefully, experts will continue to test Nuedexta and learn more about it. There are still many things that we need to learn.
 

Dealing With Nuedexta Withdrawal Symptoms

Withdrawal Symptoms of Nuedexta

If you have been taking Nuedexta for some time, and plan to cease using this medication, you are going to have to deal with withdrawal symptoms. Nuedexta withdrawal isn’t as severe as withdrawal symptoms from many other types of drugs. With that said, it can and does cause issues.
 
Follow these steps if you want to manage your Nuedexta withdrawal symptoms effectively.
 
Communicate With Your Doctor
If you’re going to stop taking Nuedexta, you need to consult with your doctor. Your doctor will be able to advise you on how you should approach this. They may recommend that you wean yourself off of Nuedexta rather than quitting it cold turkey.
 
If you’re in communication with your doctor, they will also be able to prepare you for the symptoms that you are going to be facing. They will be able to describe many of the most common symptoms of withdrawal. If you know that these signs are coming, they won’t catch you off guard.
 
Take It Easy
You shouldn’t make any big plans when you are withdrawing from a medication. Withdrawal can take a serious toll on the body. It is best to take things easy during this time.
 
You’ll want to drink a lot of water during the withdrawal process. Proper hydration won’t stop your symptoms, but it will make them a lot more manageable. Rest up and give your body a chance to recover.
 
Demonstrate Extra Caution
You should try to avoid eating new foods or visiting new areas while you’re weaning yourself off of medication. Why is this? If you’re exposed to new allergens, you could mistake an allergic reaction for withdrawal symptoms. You may not realize how these things are affecting your body.
If you’re going withdrawal, you shouldn’t try anything new. You should stick to the things that your body is already familiar with. Wait until your body has recovered before you branch out and try new things. Our bodies send us signals when something is wrong, and you need to make sure that you will be able to pick up on those signals.
 
Monitor Your Symptoms
It’s a smart idea to keep track of any symptoms that you experience. When you think that you are feeling the effects of withdrawal, you should make a note of those symptoms. You should communicate with your doctor and let them know about the symptoms you are experiencing.
 
Monitoring your symptoms makes it easier to determine how your body is responding to the withdrawal process. Regular monitoring may also allow doctors to identify symptoms that don’t have anything to do with the withdrawal. Providing your doctor with more information is always a good thing. Make sure you track your symptoms.
 
If you’re going to be dealing with withdrawal symptoms from the Nuedexta drug, you need to be prepared. If you plan ahead and follow these guidelines, you should be able to stop taking this medication. Ceasing use of medication can cause issues, but there are plenty of ways to mitigate that.

What You Should Know About Nuedexta Patient Assistance Program

Nuedexta Patient Assistance Program

 
A Patient Assistance Program recently launched for the drug Nuedexta is aimed at assisting people who have been diagnosed with Pseudobulbar affect (PBA). This program is aimed at getting these patients medication which treats this condition at no or a low cost.
 
PBA is a type of neurologic disease that in some cases occur in individuals with ALS (amyotrophic lateral sclerosis). The condition causes unwanted episodes that include either laughing or crying that do not necessarily correlate with the person’s real mood. Even though the disease is not recognized as harmful, the episodes are in most cases embarrassing and upsetting, and these people often avoid going out in public or social situations due to them.
 
Patient Assistane Program for NuedextaUnder this patient assistance program, the eligible individuals that have ALS can receive a six-month supply of Nuedexta for free and can also qualify for an ongoing assistance that includes periodic verification in regards to eligibility.
 
This Patient Assistance Program forms part of the Avanir’s Nuedexta Patient Services for health-care providers and patients. People in search of treatment and financial support can make use of these services to access the Health Insurance Plan assistance, which includes the drug-benefit verification, co-pay, and financial aid, along with information about Nuedexta and pseudobulbar affect.
 
The Financial Assistance Includes:
•The Co-Pay Assistance Program for individuals that have private insurance will set a $30 limit to the Co-Pay needed to purchase Nuedexta
 
•The Out-Of-Pocket Assistance Program are for patients with Medicare Part D which can decrease out-of-pocket expenses spent on medications such as Nuedexta
 
•The Patient Assistance Program is in place to assist people who either have no prescription medication or limited coverage to obtain the drug Nuedexta for free.
 
 
Nuedexta is a drug that decreases unwanted crying and laughing. The drug combines two different types of medications that include quinidine sulfate and dextromethorphan hydrobromide. The Dextromethorphan works in the person’s central nervous system to reduce how frequently person experiences unwanted episodes related to crying or laughing. To date, the exact mechanism of why this works is still unknown. Quinidine is what increases the blood levels of the drug Dextromethorphan in the way of interfering with how it breaks down within the body.
 
In 2010 Avanir reported on the phase three trial of Nuedexta, the previous versions were known as AVP923, Zenvia, and Neurodex. This trial included around 300 participants with the diagnosis of PBA secondary to MS (multiple sclerosis) or ALS. Investigators went on to find that this drug was able to reduce the number of episodes in association to crying or laughing when compared to the participants who were given the placebo. These investigators also concluded that the drug was well-tolerated and generally safe.
 
Individuals who have ALS and experience the pseudobulbar affect who are interested in the assistance programs can contact the Nuedexta Patient Services helpline on (855) 468-3339 from Monday to Friday between 9.00am and 7.00pm.

Is Nuedexta A Psychotropic Drug?

Nuedexta as a Psychotropic

 
A psychotropic drug is a type of drug that is used to treat psychiatric conditions. Doctors prescribe some psychotropics fairly commonly. Ambien is a popular sleep aid; Prozac is a popular anti-depressant. It’s not unusual to see people taking psychotropic drugs on a regular basis.
Can Nuedexta be classified as a psychotropic drug
 
Some people have wondered whether Nuedexta, a drug that is used to treat neurological conditions, qualifies as a psychotropic. It’s true that this medication commonly addresses issues with the brain. However, most people do not consider it to be mind-altering.
 

What Is Nuedexta?

If Nuedexta isn’t a psychotropic, then what is it? It’s classified as a central nervous system or CNS agent. It can affect the brain because it impacts the nervous system.
 

Why Isn’t Nuedexta A Psychotropic?

Generally speaking, Nuedexta isn’t used to treat any psychiatric conditions. More often than not, it treats medical problems. A prescription of Nuedexta is for people that experience uncontrollable crying or laughing because of a neurological disorder. It’s easy to mistake those kinds of symptoms for psychiatric problems, but they certainly aren’t the same thing.
 

Who Is Being Prescribed Nuedexta?

Nuedexta is commonly used to treat people with ALS, or Lou Gehring’s Disease. This drug has helped a lot of individuals to reduce the severity of their symptoms. This medication is also being prescribed to Alzheimer’s patients. Drugs like Nuedexta can treat some common neurological symptoms.
 
More recently, people have been using Neudexta to help adults with autism. Because autism is a neurological disorder, it has been quite useful. It has even been prescribed to people with brain injuries. If someone experiences the PseudoBulbar Affect, a neurological condition that causes people to experience involuntary episodes of laughing or crying, it is likely that they will be given this drug.
 

Will Nuedextra Be Classified As A Psychotropic Drug In The Future?

It is unlikely that the classification of this medication will be fall under a psychotropic listing at any point in the future. Even if it is used to treat psychiatric conditions at some point, the drug will remain a CNS agent. There is no reason for experts to change its classification.
 

How Can I Learn More About Nuedexta?

If you believe that you would benefit from taking Nuedexta, you should talk to your doctor about it. Tell them that you have heard Nuedexta has a positive effect on people that experience the PseudoBulbar Affect. See if your doctor thinks this drug would help you.
 
Like any other drug, Nuedexta does have said effects. With that said, early testing surrounding this drug has been extremely positive. If you are a patient that would benefit from Nuedexta, it is likely that your doctor will be willing to prescribe it to you.
 
Now that you know a little bit more about psychotropics and Nuedexta, you are ready to have a conversation with your doctor. Don’t be afraid to talk to your doctor about medications that might help you. After all, managing your health is part of your doctor’s job.

Can Nuedexta Cause Weight Gain?

 

Nuedexta is a medication that is primarily prescribed for the treatment of pseudobulbar effect, a mental and mood disorder. It may occur for a wide variety of reasons, including individuals who have a stroke, ALS, and multiple sclerosis. The condition is often seen with uncontrollable and inappropriate crying or laughing outbursts.

Many doctors have also begun to prescribe Nuedexta for other reasons as well, such as for the treatment of Alzheimer’s disease. The two ingredients in this medication, dextromethorphan, and quinidine work together to treat the condition. Dextromethorphan operates in the brain, and quinidine works to help that medication. It is unsure how the medicine works, but it has been shown to relieve some of the symptoms.

Some people who had been prescribed Nuedexta or who have just started using it are wondering if it may cause weight gain. There are a number of side effects that may be associated with using this medication, including dizziness, vomiting, diarrhea, weakness, coughing and swelling in the extremities. Some people may also experience drowsiness. As is the case with any medication, you should always tell your doctor if you have any persistent or difficult to manage side effects to any medication.

is a side effect of Nuedexta weight gainSome people have also had a difficulty with weight gain when taking Nuedexta, but it does not seem to be a common problem. This may be an issue that is directly associated with taking this drug, but it may also be due to a combination of medications that are prescribed by your physician or perhaps even one of the other medications that you are currently taking. This is also a side effect that you should be discussing with your doctor if it occurs, as there may be ways to control the problem or to overcome it.

If you experience weight gain when taking Nuedexta, your doctor will help you to decide if you should continue taking it. It might be decided that the benefits of using this medication far outweigh any side effects that may be experienced. He may also have suggestions as to how you can lose weight as well, depending on your medical condition and some other factors.

Your doctor prescribed Nuedexta because he felt it was the best choice for you and that the benefits of using the drug would outweigh the potential for side effects. Weight gain is not considered to be a severe side effect, and it is associated with taking many different types of medicine. It is something that you can discuss with your doctor. Of course, if you have any serious side effects, such as signs of infection, jaundice, abdominal pain, dark urine, fainting, irregular heartbeat or severe dizziness, it should be discussed with your physician without delay.

Nuedexta is a medication that has helped many people with their symptoms. No drug is perfect in its ability to treat the symptoms in all individuals. Sometimes, it takes a few tries by your physician before the right medication or combination of drugs is discovered.

Can Nuedexta Cause Headaches?

It is estimated that approximately 2 million people in the United States are affected by a condition, known as the Pseudo-Bulbar effect. It results in bouts of inappropriate and uncontrollable crying or laughing. Typically, it is associated with a brain injury or other conditions, such as Parkinson’s disease, Alzheimer’s, Lou Gehrig’s disease, stroke and multiple sclerosis. Your doctor may prescribe Nuedexta to treat the symptoms of this condition.

Headache from Nuedexta?

Many people who have been prescribed Nuedexta are wondering if headaches are a side effect of the medication. Other individuals who may already be taking the drug and have a headache wonder if it is associated with the medication or if it is just a random event. Taking a closer look at the side effects can help answer that question and see if it is something that should be discussed with your physician.

Headache with NuedextaThere are some side effects that may be associated with using Nuedexta, including dizziness, diarrhea, vomiting, coughing, weakness, and drowsiness. Although headaches are not typically listed as one of the primary potential side effects of this drug, it has been reported by some individuals. According to at least one study, approximately 13% of those who use Nuedexta report a headache as a side effect. Does that mean that it is likely that you are going to have this problem as well?

Before the time that your physician prescribes Nuedexta, he will discuss your current medical condition and any other medications that you are using. Knowing this information can help to reduce the possibility of side effects, including a headache. At times, drug interactions can lead to unexpected side effects, which is something that the doctor is trying to avoid by having a list of medications that you are taking. The same can also be true for your current medical condition, as there may be certain factors that could increase your possibility for headaches.

Another issue that may be associated with using Nuedexta are some severe drug interactions. These are also things that need to be checked on prior to the time that you are provided with a prescription. For example, Nuedexta may not work well with certain tricyclic antidepressants, digoxin or aliskiren. There may also be other medications that affect how quinidine, one of the medications in Nuedexta, is removed from the body. Using this drug along with a MAO inhibitor could cause potentially fatal drug interactions.

One of the most important things to keep in mind is that all side effects should be discussed with your physician if they become a problem. Regardless of whether it is a headache, nausea or any other problem you are experiencing, your doctor may be able to come up with a solution to reduce the issue or to remove it altogether. Headaches are not typically a severe side effect, but if they should happen become serious, you should seek medical attention without delay. More than likely, you will be able to use Nuedexta without headaches, but you should always watch for the potential problem.

A Look At Nuedexta, Avanir Pharmaceuticals

Avanir Pharmaceuticals makers of Nuedexta
Image courtesy of https://americanmigrainefoundation.org/american-registry-migraine-research/

PseudoBulbar Affect (PBA) affects approximately 2 million people within the United States and much more worldwide. It is a neurological condition and is often associated with different types of brain injuries, including those that occur with a stroke, multiple sclerosis, Parkinson’s disease and Alzheimer’s. The most common symptom of PBA is an uncontrolled and inappropriate laughing or crying. The only FDA approved treatment for the symptoms of PBA is Nuedexta.

Nuedexta contains two primary ingredients, dextromethorphan, and quinidine. These medications have been used separately for the treatment of other conditions, but when used together, they may be able to help reduce or eliminate the symptoms of PBA in some individuals. In clinical trials, it has been shown that it reduced the involuntary laughing and crying that is associated with the condition. In fact, in a 12-week study, patients experienced, on average, 82% fewer episodes of PBA. These results are promising, considering that a placebo only led to a 45% reduction. Over half of the patients had eliminated PBA episodes by the final two weeks of the study.

Avanir Pharmaceuticals is a biopharmaceutical company that is primarily focused on producing medicines that help individuals who have disorders of the central nervous system. One of those medications, available by prescription only, is Nuedexta. In October 2010, Avanir Pharmaceuticals obtained approval for Nuedexta from the US Food and Drug Administration (FDA). Since then, they had also received marketing authorization from the European Union in 2013. As of this date, it is approved for use in the United States, European Union, Norway, and Iceland.

The two different medications in Nuedexta work in conjunction with each other to reduce the symptoms of PBA. Dextromethorphan is commonly prescribed as a cough suppressant on its own. It affects the brain cycles that trigger the reflex of coughing. It is not effective at treating coughing associated with asthma, smoking or emphysema. Quinidine is commonly prescribed on its own as an antiarrhythmic medication to treat conditions such as atrial flutter and atrial fibrillation. It may also be used for the treatment of malaria.




It’s not entirely understood how the combination of medications works to reduce the symptoms of PBA. It is thought, however, that it regulates excitatory neurotransmissions with the Sigma-1 receptor antagonist activity. It may also have an effect on the NMDA receptor antagonist activity as well. This effect is thought to be due to the actions of Dextromethorphan, with Quinidine helping to reduce how quickly the Dextromethorphan breaks down in the brain.

Nuedexta was given FDA approval after a phase III clinical trial. This clinical trial enrolled patients who had multiple sclerosis or Lou Gehrig’s disease. Over the course of 12 weeks, they were either provided with Nuedexta or a placebo. The study was conducted to determine if the crying and laughing episodes could be reduced. The study concluded that those events were reduced significantly by the group that used Nuedexta in comparison to those that used the placebo. A similar study was performed for CHMP approval.

When the drug was first introduced in 2006, the FDA did not give its approval. They felt, at the time, that there were some issues associated with heart rhythm safety. The concern was primarily over quinidine and the possibility that it led to QT prolongation, which could be linked to an increased risk of heart attack. Nuedexta was then reformulated so that a lower dose of quinidine was included. New studies were conducted so that approval could be received.

Although Nuedexta has been prescribed for use in those with PBA, it may also be prescribed for other conditions as well. Some physicians are giving the prescription for agitation associated with Alzheimer’s disease, and it may also be prescribed for severe depression as well. The doctor can make the determination why this medication should be prescribed.

Nuedexta has shown real promise in helping individuals with a critical condition to lead a life that is free of the symptoms. It may also be beneficial for other conditions as well. Talk to your doctor about the possibility of using this medication and discuss your current medication usage and medical history. You may just find that it is the best option for you.