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Learn more about the medication, Nuedexta for helping treat PseudoBulbar Affect (PBA) and other conditions of the brain including dementia, ALS, and autism.
Learn more about the medication, Nuedexta for helping treat PseudoBulbar Affect (PBA) and other conditions of the brain including dementia, ALS, and autism.
Nuedexta is a drug that is effectively used to treat pseudobulbar affect which is a disorder that occurs in patients who have suffered a stroke, multiple sclerosis, or ALS. The condition causes the sufferer to laugh and cry inappropriately and involuntarily. The drug acts on the brain of such patients to prevent these outbursts. Nuedexta contains a combination of quinidine and dextromethorphan. Dextromethorphan would affect the signals in the brain that trigger cough reflex. Hence, it is mostly used as a cough suppressant. On the other hand, Quinidine affects the way how the heart beats. Hence, it is primarily used to treat patients with certain heart rhythm disorders. This article provides information on what is Nuedexta savings card.
Nuedexta is not recommended for patients who have heart disorders. Also, you should not use the drug if you have used a MAO inhibitor within the past 15 days. A dangerous drug interaction could occur under such circumstances. Nuedexta is not recommended for patients who have had serious allergic issues in the past. If you are taking quinine, quinidine, or mefloquine, you need to avoid this drug. You should tell your doctor if you are taking any other medications at the time of being prescribed this medication. The reason for talking to your physician is because some medicines can interact with Nuedexta.
The drug should be taken exactly as prescribed by your health care provider for the drug to work effectively. Don’t neglect the directions on your prescription label. Don’t take the medicine in larger or smaller amounts and for longer than the prescribed period. The drug is usually prescribed as one capsule per day for the first seven days and one capsule every 12 hours after that. You should not take more than two pills within 24 hours. You can take the capsules with or without food. Your doctor will check your progress on a regular basis and alter the dosage accordingly.
Ask your doctor before using a cough or cold medication while you are taking Nuedexta. Grapefruit or grapefruit juice can interact with the medicine and cause unwanted side effects. Hence, you should avoid these things when taking the medication. These are important things to consider when taking Nuedexta.
Unfortunately, the cost of Nuedexta is quite high, especially if your health insurance does not cover your medication. It costs around $850 for 60 capsules. But there is a way to reduce the price of this drug by at least 60-75%. That is by using a Nuedexta savings card. Many websites offer Nuedexta savings cards to patients. But you need to choose a reliable website to get your discount card. That may not be an easy task with a host of Nuedexta discount sites functioning out there.
Discount programs for drugs work similar to how you get discounts on motel rooms by using the AAA card. The savings card for Nuedexta is ideal for people who don’t have health insurance, self-employed individuals, and seniors. All big pharmacies and drug stores such as Rite Aid, CVS, and Walgreens accept the card. In fact, most of the independent pharmacies also accept the card. This card shouldn’t be confused with health insurance since the card is ideal for drugs that are not covered by your plan.
Nuedexta is what many might refer to as the drug of choice for treating Pseudobulbar Affect, also known as PBA. That reference is typically given by the medical community. The real question is, “what are users saying about the medication?” What kinds of reviews and testimonials are available regarding the use of Nuedexta. Let’s provide some of what the Nuedexta subscribers are saying here.
Before getting into the comments of these patients let briefly discuss some of the background and uses of the medication as well to put the testimonials in context. This will also help provide a little more reference for the statements these users have made.
We are going to make the assumption that there is already an understanding of what some of the side effects, uses of the medication, cost and other items are related to the medicine to avoid unnecessary dialog. However, if you’ve reached this article without knowledge of that detail, you can read more about those things here.
In looking at various locations and the testimonies provides, the following is what patients taking the medication have to say:
For Pseudobulbar Affect “I started nuedexta almost two months ago due to severe mood swings, angry outbursts and frequent crying episodes. Thanks to this medicine, these behaviors have pretty much stopped. I do think for two generic drugs, that the price should be lower.”
This review was offered by a commenter going by the name of riverrat on April 18th of 2016. Ten out of a possible ten was given by this reviewer, and the comment was found on the drugs.com website. Here is another from that site.
For Pseudobulbar Affect “I have MS and my mood swings were unbearable. I feel like this drug has balanced out my brain. Not only am I no longer sad and suffering, I think more rationally. I am going through a very stressful time in my life. Normally I should just want to lay in bed and cry. This drug has put ME in control of my emotions! I have tried a variety of anti depressants.. They made me feel numb . I hated them. This drug is different!!! I also have a history of self medicating with alcohol to cope with my anxiety when a very stressful situation occurs. Since I have started this med, I have no desire or urge. I’m not one to get online and write a review.. But I feel like this is helping me live again.. And I want to share the word!!”
This reviewer gave an 8 out of a possible 10 rating. The reviewer was belladonna4880, and the review was provided on August 29th, 2015.
WebMD.com also offered some oral reviews on their website. In these reviews, the age and gender of the patient are provided. Here are a couple of the most recent ones.
“I have Multiple Sclerosis. I started taken this Medication, due to uncontrollable crying. After 2 months, taking Nuedexta ONCE a day, I started to have INCREASED SPASTICITY in my hands & right calf & foot. My psychiatrist, NEVER informed me about this side effect. Just make sure, you speak with a PHARMACIST, BECAUSE most doctors don’t know anything about the medications they prescribe!! TRUST ME on that, I’m a RN.”
The ease of use rating given by this review was a four out of possible five stars. However, the other ratings were not as positive. For effectiveness and satisfaction, this rater gave both a 1 out of 5 stars. No names were attached to this review. The rater was a female between 45 and 54 years of age.
“I was on Neudexta for about a year and was in control and felt like I could do anything without fear of crying. But then I started to itch all over my body. After about a week, an itchy rash appeared. After an appointment with my neurologist he advised me to discontinue the drug. The itching and rash disappeared and the crying came back. I have other allergies that cause anaphylaxis so I stopped taking Neudexta.”
This reviewer gave 5 out of 5 stars for effectiveness, ease of use, and satisfaction. Again, there are no names offered with the review and it was provided by a female between 65 and 74 years of age.
newton 1971 says: “This has been a miracle drug for myself as I no longer have the outburst of unexpected crying and or laughter.”
His rating for effectiveness is 4 out of 4. He also gives 1 out of 4 for side effects which indicate none. His evaluation was presented May 14th, 2017.
cruiser reported, “When I first took it it was great. Now some of the crying is coming back. I wish I could find something else.”
For effectiveness, he gave 2 out of 4 possible and as far as side effects he gave a rating of 1 out of 4 indicating no side effects. He review was written October 10th, 2008.
There are other reviews of this medication available by those who have researched the subject. However, these reviewers don’t necessarily have personal experience in using the drug. An example of this review can be found at thoughtbroadcast.com.
Have you taken this medication? This community would appreciate reading your Nuedexta review. Comment below with your review of Nuedexta to help our readers.
PseudoBulbar Affect(PBA) is a highly unfortunate condition that is known for causing sudden bursts of laughter or crying in patients. These outbursts come on quickly and frequently occur throughout the day. In some cases, there may be slight sadness or amusement before an outburst, but most often the outbursts are completely unprovoked.
More than 2 million people in America have been diagnosed with PBA. Most of these patients have either suffered a brain injury or another serious neurological disorder. Also, there are another 7 million patients in the country with symptoms that suggest they may be affected by PseudoBulbar Affect. Nearly half of the people who suffer from a traumatic brain injury begin to display symptoms of PBA.
It should not be confused with a condition like depression, which may result in symptoms that seem similar at first. PBA causes extremely exaggerated emotional expressions. These expressions are rarely an indicator of how the patient actually feels. PBA is a neurological condition that stems from damage to the nervous system. Depression, on the other hand, is a psychological condition that stems from problems with the patient’s mental or emotional state.
Modern PBA Treatment.
Today, PBA is often treated with a drug called Nuedexta. This medication is a potent drug combination that was developed by Avanir Pharmaceuticals, who is also the manufacture the drug. They began producing the drug in 2013, and it has since grown to become an influential and popular source of treatment for this neurological condition.
Avanir has not released the exact mechanism of action for Nuedexta, but most professionals believe it works by regulating certain parts of the nervous system. More specifically, it controls neurotransmissions that use the sigma-1 receptor as well as the NMDA receptor. Meanwhile, it has also been shown to slow down the brains breakdown of dextromethorphan.
Each capsule contains a combination of two drugs. You will find them in either 20/10mg combinations or 30/10mg combinations. One drug is dextromethorphan hydrobromide and the second drug is quinidine sulfate.
Nuedexta was only approved by the FDA after extensive clinical trials. The most recent trial involved giving some patients Nuedexta and some patients placebo. The study was conducted for a total of 12 weeks, and professionals measured the frequency and length of episodes of crying or laughter.
The study yielded very positive results for Nuedexta. The patients that used the drug suffered from significantly fewer episodes of crying or laughter compared to the patients who were given the placebo.
Another study was conducted before receiving approval from the CHMP. This was a somewhat similar study that focused on judging the safety and effectiveness of the drug in a total of 325 patients. It lasted for a total of 12 weeks and had nearly the same results.
The Bottom Line.
Nuedexta is still a relatively new drug for treating PBA. The exact mechanism of action isn’t entirely known either. Still, it is impossible to argue with such positive results. It seems to be a very reliable treatment for patients suffering from this unfortunate condition.
Nuedexta is a medication that is primarily prescribed for the treatment of pseudobulbar effect, a mental and mood disorder. It may occur for a wide variety of reasons, including individuals who have a stroke, ALS, and multiple sclerosis. The condition is often seen with uncontrollable and inappropriate crying or laughing outbursts.
Many doctors have also begun to prescribe Nuedexta for other reasons as well, such as for the treatment of Alzheimer’s disease. The two ingredients in this medication, dextromethorphan, and quinidine work together to treat the condition. Dextromethorphan operates in the brain, and quinidine works to help that medication. It is unsure how the medicine works, but it has been shown to relieve some of the symptoms.
Some people who had been prescribed Nuedexta or who have just started using it are wondering if it may cause weight gain. There are a number of side effects that may be associated with using this medication, including dizziness, vomiting, diarrhea, weakness, coughing and swelling in the extremities. Some people may also experience drowsiness. As is the case with any medication, you should always tell your doctor if you have any persistent or difficult to manage side effects to any medication.
Some people have also had a difficulty with weight gain when taking Nuedexta, but it does not seem to be a common problem. This may be an issue that is directly associated with taking this drug, but it may also be due to a combination of medications that are prescribed by your physician or perhaps even one of the other medications that you are currently taking. This is also a side effect that you should be discussing with your doctor if it occurs, as there may be ways to control the problem or to overcome it.
If you experience weight gain when taking Nuedexta, your doctor will help you to decide if you should continue taking it. It might be decided that the benefits of using this medication far outweigh any side effects that may be experienced. He may also have suggestions as to how you can lose weight as well, depending on your medical condition and some other factors.
Your doctor prescribed Nuedexta because he felt it was the best choice for you and that the benefits of using the drug would outweigh the potential for side effects. Weight gain is not considered to be a severe side effect, and it is associated with taking many different types of medicine. It is something that you can discuss with your doctor. Of course, if you have any serious side effects, such as signs of infection, jaundice, abdominal pain, dark urine, fainting, irregular heartbeat or severe dizziness, it should be discussed with your physician without delay.
Nuedexta is a medication that has helped many people with their symptoms. No drug is perfect in its ability to treat the symptoms in all individuals. Sometimes, it takes a few tries by your physician before the right medication or combination of drugs is discovered.
PseudoBulbar Affect (PBA) affects approximately 2 million people within the United States and much more worldwide. It is a neurological condition and is often associated with different types of brain injuries, including those that occur with a stroke, multiple sclerosis, Parkinson’s disease and Alzheimer’s. The most common symptom of PBA is an uncontrolled and inappropriate laughing or crying. The only FDA approved treatment for the symptoms of PBA is Nuedexta.
Nuedexta contains two primary ingredients, dextromethorphan, and quinidine. These medications have been used separately for the treatment of other conditions, but when used together, they may be able to help reduce or eliminate the symptoms of PBA in some individuals. In clinical trials, it has been shown that it reduced the involuntary laughing and crying that is associated with the condition. In fact, in a 12-week study, patients experienced, on average, 82% fewer episodes of PBA. These results are promising, considering that a placebo only led to a 45% reduction. Over half of the patients had eliminated PBA episodes by the final two weeks of the study.
Avanir Pharmaceuticals is a biopharmaceutical company that is primarily focused on producing medicines that help individuals who have disorders of the central nervous system. One of those medications, available by prescription only, is Nuedexta. In October 2010, Avanir Pharmaceuticals obtained approval for Nuedexta from the US Food and Drug Administration (FDA). Since then, they had also received marketing authorization from the European Union in 2013. As of this date, it is approved for use in the United States, European Union, Norway, and Iceland.
The two different medications in Nuedexta work in conjunction with each other to reduce the symptoms of PBA. Dextromethorphan is commonly prescribed as a cough suppressant on its own. It affects the brain cycles that trigger the reflex of coughing. It is not effective at treating coughing associated with asthma, smoking or emphysema. Quinidine is commonly prescribed on its own as an antiarrhythmic medication to treat conditions such as atrial flutter and atrial fibrillation. It may also be used for the treatment of malaria.
It’s not entirely understood how the combination of medications works to reduce the symptoms of PBA. It is thought, however, that it regulates excitatory neurotransmissions with the Sigma-1 receptor antagonist activity. It may also have an effect on the NMDA receptor antagonist activity as well. This effect is thought to be due to the actions of Dextromethorphan, with Quinidine helping to reduce how quickly the Dextromethorphan breaks down in the brain.
Nuedexta was given FDA approval after a phase III clinical trial. This clinical trial enrolled patients who had multiple sclerosis or Lou Gehrig’s disease. Over the course of 12 weeks, they were either provided with Nuedexta or a placebo. The study was conducted to determine if the crying and laughing episodes could be reduced. The study concluded that those events were reduced significantly by the group that used Nuedexta in comparison to those that used the placebo. A similar study was performed for CHMP approval.
When the drug was first introduced in 2006, the FDA did not give its approval. They felt, at the time, that there were some issues associated with heart rhythm safety. The concern was primarily over quinidine and the possibility that it led to QT prolongation, which could be linked to an increased risk of heart attack. Nuedexta was then reformulated so that a lower dose of quinidine was included. New studies were conducted so that approval could be received.
Although Nuedexta has been prescribed for use in those with PBA, it may also be prescribed for other conditions as well. Some physicians are giving the prescription for agitation associated with Alzheimer’s disease, and it may also be prescribed for severe depression as well. The doctor can make the determination why this medication should be prescribed.
Nuedexta has shown real promise in helping individuals with a critical condition to lead a life that is free of the symptoms. It may also be beneficial for other conditions as well. Talk to your doctor about the possibility of using this medication and discuss your current medication usage and medical history. You may just find that it is the best option for you.
When it comes to medication, it’s important to remember that the “one size fits all” philosophy isn’t always going to hold true. One person may have a great experience with a particular medication, while another person may have some issues.
If you’re concerned about this, you should talk to your doctor about any medication before you start taking it. You should also try to speak to people that have taken this drug. Have conversations with them so that you can learn what you should expect.
Both Medications Treat A Number Of Conditions
Neither medication is used to treat one condition exclusively. Both medicines are used to treat a variety of conditions.
If you have depression, you could be offered many medications. The same goes for children with autism or adults with ADHD. There are plenty of ways to treat these conditions and both of these medications have been used in a number of ways.
These Medications Are Primarily Used To Treat Different Conditions
Nuedexta was designed to treat the symptoms of Pseudobulbar Affect (PBA), a secondary effect of other neurological conditions such as dementia, Amyotrophic lateral sclerosis (ALS), and Multiple sclerosis (MS). Although it has been employed in other ways since then, it’s clear that this is the primary purpose of this drug.
Zoloft was created to treat the symptoms of depression. Although doctors prescribe it for people with different conditions, this is still its most common use.
These are different types of medications, and they are often used to treat different things.
They Have Different Side Effects
One of the nice things about both of these medications is that the majority of people that take them don’t experience severe side effects. However, that doesn’t mean that the list of side effects that these medications can cause are identical.
You shouldn’t assume that the side effects for both of these medications are the same. They can cause different reactions for different people. If you aren’t familiar with the side effects for one of these drugs, you should read up on them so that you can learn more.
The Cost Isn’t The Same
The price that people will pay for these medications is going to vary based on the insurance policy that they have. That said, they don’t have the same cost. It’s easier to purchase a cheaper version of Zoloft, especially when you are willing to try the generic version of this drug. There is no generic version of the Nuedexta drug.
If savings are important to you, you should talk to your doctor about the most affordable medication options. They should be able to help you find a drug that will treat your condition without requiring you to spend a fortune.
They Can Be Combined
Doctors tend to be careful about combining medications. The way a medicine works can change when it is combined with something else.
Studies have suggested that these drugs can be safely combined. However, that doesn’t mean that you can take them together without talking to a doctor. You should always be very careful about mixing medications. You should also talk to a physician before you start taking something new. If a different doctor has prescribed a medication to you, you should speak to them about what you are currently taking.
Are you interested in learning more about the differences between Nuedexta and Zoloft? If you want to read up on these drugs, you’ll find a wealth of information. You should research these medications on your own time, but you should also talk to a doctor about them. A physician will be able to give you the information you won’t be able to find online.