Treating PBA With The Nuedexta Mechanism Of Action

Mechanism of Action – Nuedexta

PseudoBulbar Affect(PBA) is a highly unfortunate condition that is known for causing sudden bursts of laughter or crying in patients. These outbursts come on quickly and frequently occur throughout the day. In some cases, there may be slight sadness or amusement before an outburst, but most often the outbursts are completely unprovoked.

More than 2 million people in America have been diagnosed with PBA. Most of these patients have either suffered a brain injury or another serious neurological disorder. Also, there are another 7 million patients in the country with symptoms that suggest they may be affected by PseudoBulbar Affect. Nearly half of the people who suffer from a traumatic brain injury begin to display symptoms of PBA.

It should not be confused with a condition like depression, which may result in symptoms that seem similar at first. PBA causes extremely exaggerated emotional expressions. These expressions are rarely an indicator of how the patient actually feels. PBA is a neurological condition that stems from damage to the nervous system. Depression, on the other hand, is a psychological condition that stems from problems with the patient’s mental or emotional state.

Modern PBA Treatment.

Today, PBA is often treated with a drug called Nuedexta. This medication is a potent drug combination that was developed by Avanir Pharmaceuticals, who is also the manufacture the drug. They began producing the drug in 2013, and it has since grown to become an influential and popular source of treatment for this neurological condition.

Avanir has not released the exact mechanism of action for Nuedexta, but most professionals believe it works by regulating certain parts of the nervous system. More specifically, it controls neurotransmissions that use the sigma-1 receptor as well as the NMDA receptor. Meanwhile, it has also been shown to slow down the brains breakdown of dextromethorphan.

Each capsule contains a combination of two drugs. You will find them in either 20/10mg combinations or 30/10mg combinations. One drug is dextromethorphan hydrobromide and the second drug is quinidine sulfate.

Nuedexta was only approved by the FDA after extensive clinical trials. The most recent trial involved giving some patients Nuedexta and some patients placebo. The study was conducted for a total of 12 weeks, and professionals measured the frequency and length of episodes of crying or laughter.

The study yielded very positive results for Nuedexta. The patients that used the drug suffered from significantly fewer episodes of crying or laughter compared to the patients who were given the placebo.

Another study was conducted before receiving approval from the CHMP. This was a somewhat similar study that focused on judging the safety and effectiveness of the drug in a total of 325 patients. It lasted for a total of 12 weeks and had nearly the same results.

The Bottom Line

Nuedexta is still a relatively new drug for treating PBA. The exact mechanism of action isn’t entirely known either. Still, it is impossible to argue with such positive results. It seems to be a very reliable treatment for patients suffering from this unfortunate condition.

What We’ve Learned From Nuedexta Clinical Trials

Findings – Clinical Trials with Nuedexta

Nuedexta has been tested extensively, before and after its release. We’ve been able to glean a lot of information from these clinical trials. Today, we know far more about Nuedexta than we once did.
clinical research trial
What Kinds Of Results Have We Seen?
A lot of these trials have led to extremely positive results. Some of the most promising results involved using Nuedexta to treat people that have ALS. Studies have found that the drug can ease many ALS symptoms, including speech difficulties and issues with swallowing.
While a lot of these tests have been small in scale, the majority of the patients responded very positively to this drug. These studies have been extremely promising. New studies are being launched so that we can glean more information about the effectiveness of this medication.

The Goal Of These Studies

The primary goal of the research and studies involving Nuedexta is to find ways to treat ALS. Researchers are looking for ways to improve the quality of life for people with ALS. Medications like this are a big part of it.
Of course, not all of the clinical trials involving Nuedexta have been about ALS and ALS symptoms. There have also been studies that used Nuedexta to treat patients with Alzheimer’s Disease. People with Alzheimer’s often experience neurological problems. For example, people might have unexplained bouts of crying or laughter. Early research has shown that
Nuedexta can treat this effectively as well.
Nuedexta has even been tested on adults with autism. It seems clear that this medication can effectively treat all kinds of people with neurological disorders.
What’s Next?
What’s next for Nuedexta? While the medication has been approved by the FDA and is being prescribed now, experts still want to learn more about it. There will continue to be clinical trials involved Nuedexta in the future.
It is unlikely that this medication will be changed in any major way. However, it is possible that the drug will be prescribed to a larger number of people. Because trials have shown that it can treat a range of issues effectively, it seems likely that a growing number of doctors are going to be prescribing this drug to their patients.
At this current point in time, it seems unlikely that doctors will be prescribing Nuedexta to children. It is challenging to confirm that a medication like this is safe for children to take.
However, it is likely that this drug is going to be given to a growing number of people. As doctors learn more about this drug and what it is capable of, they will be far more likely to recommend it to their patients in the future.
Nuedexta clinical trials have provided us with a lot of valuable insight. Thanks to these tests, doctors will be able to prescribe Nuedexta to people that will benefit from it greatly. Hopefully, experts will continue to test Nuedexta and learn more about it. There are still many things that we need to learn.

Dealing With Nuedexta Withdrawal Symptoms

Withdrawal Symptoms of Nuedexta

If you have been taking Nuedexta for some time, and plan to cease using this medication, you are going to have to deal with withdrawal symptoms. Nuedexta withdrawal isn’t as severe as withdrawal symptoms from many other types of drugs. With that said, it can and does cause issues.
Follow these steps if you want to manage your Nuedexta withdrawal symptoms effectively.
Communicate With Your Doctor
If you’re going to stop taking Nuedexta, you need to consult with your doctor. Your doctor will be able to advise you on how you should approach this. They may recommend that you wean yourself off of Nuedexta rather than quitting it cold turkey.
If you’re in communication with your doctor, they will also be able to prepare you for the symptoms that you are going to be facing. They will be able to describe many of the most common symptoms of withdrawal. If you know that these signs are coming, they won’t catch you off guard.
Take It Easy
You shouldn’t make any big plans when you are withdrawing from a medication. Withdrawal can take a serious toll on the body. It is best to take things easy during this time.
You’ll want to drink a lot of water during the withdrawal process. Proper hydration won’t stop your symptoms, but it will make them a lot more manageable. Rest up and give your body a chance to recover.
Demonstrate Extra Caution
You should try to avoid eating new foods or visiting new areas while you’re weaning yourself off of medication. Why is this? If you’re exposed to new allergens, you could mistake an allergic reaction for withdrawal symptoms. You may not realize how these things are affecting your body.
If you’re going withdrawal, you shouldn’t try anything new. You should stick to the things that your body is already familiar with. Wait until your body has recovered before you branch out and try new things. Our bodies send us signals when something is wrong, and you need to make sure that you will be able to pick up on those signals.
Monitor Your Symptoms
It’s a smart idea to keep track of any symptoms that you experience. When you think that you are feeling the effects of withdrawal, you should make a note of those symptoms. You should communicate with your doctor and let them know about the symptoms you are experiencing.
Monitoring your symptoms makes it easier to determine how your body is responding to the withdrawal process. Regular monitoring may also allow doctors to identify symptoms that don’t have anything to do with the withdrawal. Providing your doctor with more information is always a good thing. Make sure you track your symptoms.
If you’re going to be dealing with withdrawal symptoms from the Nuedexta drug, you need to be prepared. If you plan ahead and follow these guidelines, you should be able to stop taking this medication. Ceasing use of medication can cause issues, but there are plenty of ways to mitigate that.