Author Archives: JasonScott
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The Clinical Trails of Nuedexta Medication
Nuedexta is a drug which is being used to treat people who are suffering from a condition known as Pseudobulbar affect. Nuedexta is still quite a young, and untested drug, and there are a series of clinical trials being performed at the moment to determine the effectiveness and safety of the drug.
The Nuedexta clinical trials have, so far, been quite positive and promising. It should not be long before the drug is prescribed commonly to treat people with PBA. There are always safety concerns with new medications, and the outcomes of the clinical trials so far are being watched quite closely.
Nuedexta Has Been Licensed for Marketing in Some Parts of the World
Neudexta was given a marketing license in 2013 by the EMA. The license was withdrawn for EU marketing in 2016 and did not get licensed at all for marketing in the UK. For it to be licensed, it will need far more testing than it has had so far. The drug is still available in the USA.
Effects of Nuedexta Studied in Clinical Trials
One of the most recent Nuedexta clinical trials focused on the effects of the drug on nursing home patients who suffered from PBA. The experiment spanned six months and looked at a total of 125 patients across several states. Unfortunately, evidence from this study was inconclusive because there was difficulty recruiting patients, so the study was terminated before the six month period was up.
Another study looked at the safety and tolerability of Nuedexta for managing PBR in people who had suffered from a range of conditions, including traumatic brain injury and dementia, as well as strokes. This study spanned 12 weeks and used a 20mg dose of Nuedexta. The study engaged 367 participants and showed promising results across several outcome measures relating to emotional episodes and other difficulties.
Nuedexta is Often Mis-Prescribed
Clinical trials have been promising when Nuedexta has been tested for PBA alone. However, there are some concerns about the safety of the drug and the way that it is prescribed. Recent research and studies into the prescription of the medication indicate that doctors often prescribe it to people who have dementia, Parkinson’s, or another underlying condition. This is concerning because the drug has not been tested for use in this way. It is uncertain whether there may be interactions between Nuedexta and other drugs, or whether it may have unexpected impacts on people who are suffering from other conditions. This is something that the medical community is calling for further research.
Technically, prescribing Neudexta for PBA that is associated with other underlying conditions is off-label. This is something that a lot of doctors and consultants overlook, but it should be a matter of significant concern given the potential for the drug to have unwanted side-effects.
Indeed, Medicare has asked that insurance companies monitor the prescription of Nuedexta. That’s because it is being marketed aggressively for dementia patients. Though, it has not been properly tested and trialed for that kind of use. It is also being marketed for Alzheimer’s. Other drugs are likely to be far better suited for managing the symptoms that people living with Alzheimer’s are experiencing. People who use Nuedexta for Alzheimer’s are more likely to experience falls, and other secondary issues, including UTIs, than those who are given more appropriate drugs.
One challenge that doctors face is that there are not many options for managing the behavioral issues associated with Alzheimer’s and dementia. It can be tempting to use something like Nuedexta, which may help with those issues in the short term. Unfortunately, Nuedexta is just a band-aid for such problems, and it is not going to manage the condition itself. In the vast majority of cases, it would be better for doctors to find ways to proactively slow the progress of Alzheimer’s or to find ways for the patient to cope with dementia without using an off-label drug that has not been tested for that kind of application. Doctors and nursing home workers are encouraged to avoid this kind of excessive over-prescription until more data is clarifying the safety of the drug.
Are you familiar with the combination drug Nuedexta? If so, then you may know someone who suffers from Pseudo-Bulbar Affect (PBA). This condition is relatively uncommon in the US, but it can have an enormous impact on the life of patients. It is characterized by uncontrollable episodes of laughing or crying, even if it doesn’t match how the person feels inside. Approximately 2 million individuals in the US suffer from PBA.
Nuedexta is the first-ever FDA approved treatment for PBA. It is a combination drug that includes dextromethorphan as well as the class I antiarrhythmic agent quinidine. Most patients with PBA also have some form of brain injury or other neurologic condition. Nuedexta has proven to be a lifesaver for them. However, it’s interesting to note that Nuedexta can also be used for treating other medical conditions.
Several studies have been conducted to test the efficacy of Nuedexta for treating other disorders. Early results appear to be very promising, with health experts recommending the use of Nuedexta even for patients who do not suffer from PBA. These off-label uses of the drug Nuedexta might scare off some people, with many fearing that the drug might cause certain side effects that will only worsen the condition.
Using Nuedexta to treat Parkinsons & MS, click here for your discount savings card to save up to 85% on the price of your prescription.
Alzheimer’s disease is one of the first medical conditions for which index is tested. Health experts conducted a randomized clinical trial to see how effective it will be for patients with Alzheimer’s and significant agitation. The group was divided in two. The first was provided with Nuedexta, while the other was given a placebo. It has been shown that Nuedexta was able to help patients manage their dementia symptoms better.
Similar results were seen when Nuedexta was given to people with bipolar disorder. All of the patients had some form of depressive symptoms for two years at a minimum. Following 90 days of treatment, signs of improvement were readily seen in the patients. Health experts, however, agree that more studies are necessary to have reliable evidence for proving the effectiveness of Nuedexta for treating bipolar disorder.
Scientists also conducted a study involving patients with diabetic peripheral neuropathy. The goal was to evaluate the tolerability of the combination drug with diabetic neuropathy. Interestingly, the researchers found out that the drug leads to a significant reduction in pain while also improving sleep and overall quality of life. However, it’s important to note that for this study, in particular, a higher dosage was used than normal. This change in dosage could have had a large impact on the results of the research.
As you can see, there are plenty of Nuedexta off label uses, even for some of the more severe medical conditions. This doesn’t mean, however, that you should use it for the conditions are suffering from without the guidance of a medical professional. Also, you should make sure that you take the right dose of Nuedexta to avoid potential side effects. It’s important to keep in mind that despite the promising results of different studies, more evidence is needed to fully establish the effectiveness of Nuedexta off label uses when it comes to treating other medical conditions.
The medication used to make up the Nuedexta drug is in part what is used to also treat Parkinsons and MS. While Nuedexta for Parkinsons is not a confirmed treatment for the disease, there is a clinical trial that was done that showed promising results of the use of the drug to treat the disease.
(Need help paying for your prescription? Get your discount with this savings card.)
Just like using any medication, be sure to work closely with your doctor so you can make sure that you are a perfect candidate for Nuedexta. There are instances in which the combination drug might cause more harm than good for your body. It can interact with other prescription medications you’re taking. Speak with your doctor first and ask how much to take daily and for how long. Following your physician’s instructions is always recommended to obtain optimal results.
Nuedexta is a drug that is effectively used to treat pseudobulbar affect which is a disorder that occurs in patients who have suffered a stroke, multiple sclerosis, or ALS. The condition causes the sufferer to laugh and cry inappropriately and involuntarily. The drug acts on the brain of such patients to prevent these outbursts. Nuedexta contains a combination of quinidine and dextromethorphan. Dextromethorphan would affect the signals in the brain that trigger cough reflex. Hence, it is mostly used as a cough suppressant. On the other hand, Quinidine affects the way how the heart beats. Hence, it is primarily used to treat patients with certain heart rhythm disorders. This article provides information on what is Nuedexta savings card.
Nuedexta is not recommended for patients who have heart disorders. Also, you should not use the drug if you have used a MAO inhibitor within the past 15 days. A dangerous drug interaction could occur under such circumstances. Nuedexta is not recommended for patients who have had serious allergic issues in the past. If you are taking quinine, quinidine, or mefloquine, you need to avoid this drug. You should tell your doctor if you are taking any other medications at the time of being prescribed this medication. The reason for talking to your physician is because some medicines can interact with Nuedexta.
The drug should be taken exactly as prescribed by your health care provider for the drug to work effectively. Don’t neglect the directions on your prescription label. Don’t take the medicine in larger or smaller amounts and for longer than the prescribed period. The drug is usually prescribed as one capsule per day for the first seven days and one capsule every 12 hours after that. You should not take more than two pills within 24 hours. You can take the capsules with or without food. Your doctor will check your progress on a regular basis and alter the dosage accordingly.
Ask your doctor before using a cough or cold medication while you are taking Nuedexta. Grapefruit or grapefruit juice can interact with the medicine and cause unwanted side effects. Hence, you should avoid these things when taking the medication. These are important things to consider when taking Nuedexta.
Unfortunately, the cost of Nuedexta is quite high, especially if your health insurance does not cover your medication. It costs around $850 for 60 capsules. But there is a way to reduce the price of this drug by at least 60-75%. That is by using a Nuedexta savings card. Many websites offer Nuedexta savings cards to patients. But you need to choose a reliable website to get your discount card. That may not be an easy task with a host of Nuedexta discount sites functioning out there.
Discount programs for drugs work similar to how you get discounts on motel rooms by using the AAA card. The savings card for Nuedexta is ideal for people who don’t have health insurance, self-employed individuals, and seniors. All big pharmacies and drug stores such as Rite Aid, CVS, and Walgreens accept the card. In fact, most of the independent pharmacies also accept the card. This card shouldn’t be confused with health insurance since the card is ideal for drugs that are not covered by your plan.
Nuedexta is what many might refer to as the drug of choice for treating Pseudobulbar Affect, also known as PBA. That reference is typically given by the medical community. The real question is, “what are users saying about the medication?” What kinds of reviews and testimonials are available regarding the use of Nuedexta. Let’s provide some of what the Nuedexta subscribers are saying here.
Before getting into the comments of these patients let briefly discuss some of the background and uses of the medication as well to put the testimonials in context. This will also help provide a little more reference for the statements these users have made.
We are going to make the assumption that there is already an understanding of what some of the side effects, uses of the medication, cost and other items are related to the medicine to avoid unnecessary dialog. However, if you’ve reached this article without knowledge of that detail, you can read more about those things here.
In looking at various locations and the testimonies provides, the following is what patients taking the medication have to say:
For Pseudobulbar Affect “I started nuedexta almost two months ago due to severe mood swings, angry outbursts and frequent crying episodes. Thanks to this medicine, these behaviors have pretty much stopped. I do think for two generic drugs, that the price should be lower.”
This review was offered by a commenter going by the name of riverrat on April 18th of 2016. Ten out of a possible ten was given by this reviewer, and the comment was found on the drugs.com website. Here is another from that site.
For Pseudobulbar Affect “I have MS and my mood swings were unbearable. I feel like this drug has balanced out my brain. Not only am I no longer sad and suffering, I think more rationally. I am going through a very stressful time in my life. Normally I should just want to lay in bed and cry. This drug has put ME in control of my emotions! I have tried a variety of anti depressants.. They made me feel numb . I hated them. This drug is different!!! I also have a history of self medicating with alcohol to cope with my anxiety when a very stressful situation occurs. Since I have started this med, I have no desire or urge. I’m not one to get online and write a review.. But I feel like this is helping me live again.. And I want to share the word!!”
This reviewer gave an 8 out of a possible 10 rating. The reviewer was belladonna4880, and the review was provided on August 29th, 2015.
WebMD.com also offered some oral reviews on their website. In these reviews, the age and gender of the patient are provided. Here are a couple of the most recent ones.
“I have Multiple Sclerosis. I started taken this Medication, due to uncontrollable crying. After 2 months, taking Nuedexta ONCE a day, I started to have INCREASED SPASTICITY in my hands & right calf & foot. My psychiatrist, NEVER informed me about this side effect. Just make sure, you speak with a PHARMACIST, BECAUSE most doctors don’t know anything about the medications they prescribe!! TRUST ME on that, I’m a RN.”
The ease of use rating given by this review was a four out of possible five stars. However, the other ratings were not as positive. For effectiveness and satisfaction, this rater gave both a 1 out of 5 stars. No names were attached to this review. The rater was a female between 45 and 54 years of age.
“I was on Neudexta for about a year and was in control and felt like I could do anything without fear of crying. But then I started to itch all over my body. After about a week, an itchy rash appeared. After an appointment with my neurologist he advised me to discontinue the drug. The itching and rash disappeared and the crying came back. I have other allergies that cause anaphylaxis so I stopped taking Neudexta.”
This reviewer gave 5 out of 5 stars for effectiveness, ease of use, and satisfaction. Again, there are no names offered with the review and it was provided by a female between 65 and 74 years of age.
newton 1971 says: “This has been a miracle drug for myself as I no longer have the outburst of unexpected crying and or laughter.”
His rating for effectiveness is 4 out of 4. He also gives 1 out of 4 for side effects which indicate none. His evaluation was presented May 14th, 2017.
cruiser reported, “When I first took it it was great. Now some of the crying is coming back. I wish I could find something else.”
For effectiveness, he gave 2 out of 4 possible and as far as side effects he gave a rating of 1 out of 4 indicating no side effects. He review was written October 10th, 2008.
There are other reviews of this medication available by those who have researched the subject. However, these reviewers don’t necessarily have personal experience in using the drug. An example of this review can be found at thoughtbroadcast.com.
Have you taken this medication? This community would appreciate reading your Nuedexta review. Comment below with your review of Nuedexta to help our readers.
PseudoBulbar Affect(PBA) is a highly unfortunate condition that is known for causing sudden bursts of laughter or crying in patients. These outbursts come on quickly and frequently occur throughout the day. In some cases, there may be slight sadness or amusement before an outburst, but most often the outbursts are completely unprovoked.
More than 2 million people in America have been diagnosed with PBA. Most of these patients have either suffered a brain injury or another serious neurological disorder. Also, there are another 7 million patients in the country with symptoms that suggest they may be affected by PseudoBulbar Affect. Nearly half of the people who suffer from a traumatic brain injury begin to display symptoms of PBA.
It should not be confused with a condition like depression, which may result in symptoms that seem similar at first. PBA causes extremely exaggerated emotional expressions. These expressions are rarely an indicator of how the patient actually feels. PBA is a neurological condition that stems from damage to the nervous system. Depression, on the other hand, is a psychological condition that stems from problems with the patient’s mental or emotional state.
Modern PBA Treatment.
Today, PBA is often treated with a drug called Nuedexta. This medication is a potent drug combination that was developed by Avanir Pharmaceuticals, who is also the manufacture the drug. They began producing the drug in 2013, and it has since grown to become an influential and popular source of treatment for this neurological condition.
Avanir has not released the exact mechanism of action for Nuedexta, but most professionals believe it works by regulating certain parts of the nervous system. More specifically, it controls neurotransmissions that use the sigma-1 receptor as well as the NMDA receptor. Meanwhile, it has also been shown to slow down the brains breakdown of dextromethorphan.
Each capsule contains a combination of two drugs. You will find them in either 20/10mg combinations or 30/10mg combinations. One drug is dextromethorphan hydrobromide and the second drug is quinidine sulfate.
Nuedexta was only approved by the FDA after extensive clinical trials. The most recent trial involved giving some patients Nuedexta and some patients placebo. The study was conducted for a total of 12 weeks, and professionals measured the frequency and length of episodes of crying or laughter.
The study yielded very positive results for Nuedexta. The patients that used the drug suffered from significantly fewer episodes of crying or laughter compared to the patients who were given the placebo.
Another study was conducted before receiving approval from the CHMP. This was a somewhat similar study that focused on judging the safety and effectiveness of the drug in a total of 325 patients. It lasted for a total of 12 weeks and had nearly the same results.
The Bottom Line.
Nuedexta is still a relatively new drug for treating PBA. The exact mechanism of action isn’t entirely known either. Still, it is impossible to argue with such positive results. It seems to be a very reliable treatment for patients suffering from this unfortunate condition.
Nuedexta is a medication that is primarily prescribed for the treatment of pseudobulbar effect, a mental and mood disorder. It may occur for a wide variety of reasons, including individuals who have a stroke, ALS, and multiple sclerosis. The condition is often seen with uncontrollable and inappropriate crying or laughing outbursts.
Many doctors have also begun to prescribe Nuedexta for other reasons as well, such as for the treatment of Alzheimer’s disease. The two ingredients in this medication, dextromethorphan, and quinidine work together to treat the condition. Dextromethorphan operates in the brain, and quinidine works to help that medication. It is unsure how the medicine works, but it has been shown to relieve some of the symptoms.
Some people who had been prescribed Nuedexta or who have just started using it are wondering if it may cause weight gain. There are a number of side effects that may be associated with using this medication, including dizziness, vomiting, diarrhea, weakness, coughing and swelling in the extremities. Some people may also experience drowsiness. As is the case with any medication, you should always tell your doctor if you have any persistent or difficult to manage side effects to any medication.
Some people have also had a difficulty with weight gain when taking Nuedexta, but it does not seem to be a common problem. This may be an issue that is directly associated with taking this drug, but it may also be due to a combination of medications that are prescribed by your physician or perhaps even one of the other medications that you are currently taking. This is also a side effect that you should be discussing with your doctor if it occurs, as there may be ways to control the problem or to overcome it.
If you experience weight gain when taking Nuedexta, your doctor will help you to decide if you should continue taking it. It might be decided that the benefits of using this medication far outweigh any side effects that may be experienced. He may also have suggestions as to how you can lose weight as well, depending on your medical condition and some other factors.
Your doctor prescribed Nuedexta because he felt it was the best choice for you and that the benefits of using the drug would outweigh the potential for side effects. Weight gain is not considered to be a severe side effect, and it is associated with taking many different types of medicine. It is something that you can discuss with your doctor. Of course, if you have any serious side effects, such as signs of infection, jaundice, abdominal pain, dark urine, fainting, irregular heartbeat or severe dizziness, it should be discussed with your physician without delay.
Nuedexta is a medication that has helped many people with their symptoms. No drug is perfect in its ability to treat the symptoms in all individuals. Sometimes, it takes a few tries by your physician before the right medication or combination of drugs is discovered.